Results 81 to 90 of about 151,084 (348)

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

Arthritis Research & Therapy, 2018
BackgroundIL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony ankylosis.
S. Jo, S. E. Wang, Y. L. Lee, Suman Kang, Bitnara Lee, Jinil Han, I. Sung, Ye-Soo Park, S. Bae, Tae-Hwan Kim   +9 more
semanticscholar   +1 more source

Spino‐Pelvic Alignment and Surgical Outcomes in Chinese Elderly With Lumbar Stenosis Syndrome: A Prospective Study

AGING MEDICINE, EarlyView.
This study highlights the critical role of maintaining spino‐pelvic alignment in elderly patients with lumbar spinal stenosis. Postsurgical thresholds for PI‐LL (17.7°) and PT (26.1°) were associated with improved clinical outcomes, offering valuable benchmarks for surgical planning and postoperative care to enhance quality of life.
Chong Zhao, Linyu Jin, Yan Liang, Haiying Liu, Shuai Xu   +4 more
wiley   +1 more source

PSORIATIC ARTHRITIS: AN ALGORITHM FOR MAKING A DECISION ON THE CHOICE OF MANAGEMENT TACTICS

Klinicist, 2016
Psoriatic arthritis (PA) is a chronic inflammatory disease of the joints, vertebral column, and entheses from a group of seronegative spondyloarthritides, which is observed in patients with psoriasis.
N. A. Shostak, A. A. Klimenko, D. A. Anichkov, A. A. Kondrashov   +3 more
doaj   +1 more source

Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]

, 1993
In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A., Dawes, Peter T., Hothersall, T.E.   +2 more
core  

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources

Modified stoke ankylosing spondylitis spinal score as an outcome measure to assess the impact of treatment on structural progression in ankylosing spondylitis

Rheumatology, 2018
In ankylosing spondylitis (AS), structural damage that occurs as a result of syndesmophyte formation and ankylosis of the vertebral column is irreversible.
D. van der Heijde, J. Braun, A. Deodhar, X. Baraliakos, R. Landewé, H. Richards, B. Porter, A. Readie   +7 more
semanticscholar   +1 more source

An epidemiological assessment of lens opacifications that impaired vision in patients injected with radium-224 [PDF]

, 1988
The incidence of lens opacifications that impaired vision (cataract) was analyzed among 831 patients who were injected with known dosages of 224Ra in Germany shortly after World War II.
Chmelevsky, D., Kellerer, Albrecht M., Mays, C. W., Spiess, H., Stefani, F.-H.   +4 more
core   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, EarlyView.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

A comparison of three methods to generate a conceptual understanding of a disease based on the patients’ perspective

Journal of Patient-Reported Outcomes, 2017
Background The Food and Drug Administration patient-reported outcome (PRO) guidance provides standards for PRO development, but these standards bring scientific and logistical challenges which can result in a lengthy and expensive instrument development ...
Louise Humphrey, Thomas Willgoss, Andrew Trigg, Stephanie Meysner, Mary Kane, Sally Dickinson, Helen Kitchen   +6 more
doaj   +1 more source

A case of ankylosing spondylitis presenting with fever of unknown origin diagnosed as aortitis: A case report

Clinical Case Reports, 2023
Key Clinical Message Clinicians should be aware of rare manifestations of AS, while considering a low threshold for screening vascular involvement in an axial SpA/nrxSpA/AS presenting with unexplained fevers and significant constitutional symptoms and ...
Mahsa Mehdipour Dalivand, Rezvan Abdolazimi, Reyhaneh Manafi‐Farid, Ahmadreza Jamshidi, Kimia Kassaee, Sara Foolad, Majid Alikhani   +6 more
doaj   +1 more source