Results 31 to 40 of about 266,735 (210)

Spontaneous Neural Dynamics and Multi-scale Network Organization

Frontiers in Systems Neuroscience, 2016
Spontaneous neural activity has historically been viewed as task-irrelevant noise that should be controlled for via experimental design, and removed through data analysis.
Brett L. Foster, Biyu J. He, Christopher J. Honey, Karim eJerbi, Alexander eMaier, Yuri B. Saalmann   +5 more
doaj   +1 more source

Eyes-Open and Eyes-Closed Resting States With Opposite Brain Activity in Sensorimotor and Occipital Regions: Multidimensional Evidences From Machine Learning Perspective

Frontiers in Human Neuroscience, 2018
Studies have demonstrated that there are widespread significant differences in spontaneous brain activity between eyes-open (EO) and eyes-closed (EC) resting states.
Jie Wei, Jie Wei, Jie Wei, Tong Chen, Tong Chen, Tong Chen, Chuandong Li, Chuandong Li, Guangyuan Liu, Guangyuan Liu, Jiang Qiu, Dongtao Wei   +11 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation

Frontiers in Neural Circuits
Unlike digital computers, the brain exhibits spontaneous activity even during complete rest, despite the evolutionary pressure for energy efficiency.
Narumitsu Ikeda, Dai Akita, Hirokazu Takahashi, Hirokazu Takahashi   +3 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Brain interleukin-1β and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats. [PDF]

PLoS ONE, 2014
During acute viral infections such as influenza, humans often experience not only transient fever, but also prolonged fatigue or depressive feelings with a decrease in social activity for days or weeks.
Masanori Yamato, Yasuhisa Tamura, Asami Eguchi, Satoshi Kume, Yukiharu Miyashige, Masayuki Nakano, Yasuyoshi Watanabe, Yosky Kataoka   +7 more
doaj   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI.

PLoS ONE, 2013
Mitochondrial Ca(2+) uptake, central to neural metabolism and function, is diminished in aging whereas enhanced after acute/sub-acute traumatic brain injury. To develop relevant translational models for these neuropathologies, we determined the impact of
Basavaraju G Sanganahalli, Peter Herman, Fahmeed Hyder, Sridhar S Kannurpatti   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bridging Single Neuron Dynamics to Global Brain States

Frontiers in Systems Neuroscience, 2019
Biological neural networks produce information backgrounds of multi-scale spontaneous activity that become more complex in brain states displaying higher capacities for cognition, for instance, attentive awake versus asleep or anesthetized states.
Jennifer S. Goldman, Núria Tort-Colet, Matteo di Volo, Eduarda Susin, Jules Bouté, Melissa Dali, Mallory Carlu, Trang-Anh Nghiem, Tomasz Górski, Alain Destexhe   +9 more
doaj   +1 more source