Results 41 to 50 of about 7,850,544 (208)

Brain interleukin-1β and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats. [PDF]

PLoS ONE, 2014
During acute viral infections such as influenza, humans often experience not only transient fever, but also prolonged fatigue or depressive feelings with a decrease in social activity for days or weeks.
Masanori Yamato, Yasuhisa Tamura, Asami Eguchi, Satoshi Kume, Yukiharu Miyashige, Masayuki Nakano, Yasuyoshi Watanabe, Yosky Kataoka   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI.

PLoS ONE, 2013
Mitochondrial Ca(2+) uptake, central to neural metabolism and function, is diminished in aging whereas enhanced after acute/sub-acute traumatic brain injury. To develop relevant translational models for these neuropathologies, we determined the impact of
Basavaraju G Sanganahalli, Peter Herman, Fahmeed Hyder, Sridhar S Kannurpatti   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bridging Single Neuron Dynamics to Global Brain States

Frontiers in Systems Neuroscience, 2019
Biological neural networks produce information backgrounds of multi-scale spontaneous activity that become more complex in brain states displaying higher capacities for cognition, for instance, attentive awake versus asleep or anesthetized states.
Jennifer S. Goldman, Núria Tort-Colet, Matteo di Volo, Eduarda Susin, Jules Bouté, Melissa Dali, Mallory Carlu, Trang-Anh Nghiem, Tomasz Górski, Alain Destexhe   +9 more
doaj   +1 more source

Hemodynamic and electrophysiological evidence of resting-state network activity in the primate [PDF]

, 2008
An expanding body of literature describes the existence of concerted brain activations in the absence of any external stimuli. Resting-state networks have been identified and demonstrated to be modulated during the performance of specific cognitive ...
Wei Shen, Felix Darvas, Allen Ardestani, Joaquin Fuster, Arthur Toga   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Electrically coupled inhibitory interneurons constrain long-range connectivity of cortical networks

NeuroImage, 2020
Spontaneous infra-slow brain activity (ISA) exhibits a high degree of temporal synchrony, or correlation, between distant brain regions. The spatial organization of ISA synchrony is not explained by anatomical connections alone, suggesting that active ...
Andrew W. Kraft, Anish Mitra, Zachary P. Rosenthal, Nico U.F. Dosenbach, Adam Q. Bauer, Abraham Z. Snyder, Marcus E. Raichle, Joseph P. Culver, Jin-Moo Lee   +8 more
doaj   +1 more source

Precision dynamical mapping using topological data analysis reveals a hub-like transition state at rest

Nature Communications, 2022
Although spontaneous brain activity is complex and clinically relevant, it is still unclear whether transitions in resting brain activity follow an underlying arrangement or whether they are unpredictable.
Manish Saggar, James M. Shine, Raphaël Liégeois, Nico U. F. Dosenbach, Damien Fair   +4 more
doaj   +1 more source