Results 61 to 70 of about 803,284 (272)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Nonlinear characterisation of a silicon integrated Bragg waveguide filter

, 2018
Bragg waveguides are promising optical filters for pump suppression in spontaneous Four-Wave Mixing (FWM) photon sources. In this work, we investigate the generation of unwanted photon pairs in the filter itself.
Baehr-Jones, Tom, Bajoni, Daniele, Bergamasco, Nicola, Galland, Christophe, Galli, Matteo, Harris, Nicholas C., Hochberg, Michael, Liscidini, Marco, Massara, Micol Previde, Menotti, Matteo   +9 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Sensory feedback synchronizes motor and sensory neuronal networks in the neonatal rat spinal cord

Nature Communications, 2016
Spontaneous movements are important for mammalian development but how network activity underlies the generation of these actions remains unclear. Here the authors show that both spontaneous twitches and complex movements enable correlated activity in ...
Ana R. Inácio, Azat Nasretdinov, Julia Lebedeva, Roustem Khazipov   +3 more
doaj   +1 more source

Spontaneously generated tensor field gravity [PDF]

Nuclear Physics B, 2011
An arbitrary local theory of a symmetric two-tensor field $H_{ }$ in Minkowski spacetime is considered, in which the equations of motion are required to be compatible with a nonlinear length-fixing constraint $H_{ }^{2}=\pm M^{2}$ leading to spontaneous Lorentz invariance violation, SLIV ($M$ is the proposed scale for SLIV).
Chkareuli, J.L., Frogatt, C.D., Nielsen, Holger Frits Bech   +2 more
openaire   +4 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Spontaneous generation of mammalian prions [PDF]

Proceedings of the National Academy of Sciences, 2010
Prions are transmissible agents that cause lethal neurodegeneration in humans and other mammals. Prions bind avidly to metal surfaces such as steel wires and, when surface-bound, can initiate infection of brain or cultured cells with remarkable efficiency.
Julie A, Edgeworth, Nathalie, Gros, Jack, Alden, Susan, Joiner, Jonathan D F, Wadsworth, Jackie, Linehan, Sebastian, Brandner, Graham S, Jackson, Charles, Weissmann, John, Collinge   +9 more
openaire   +2 more sources

Spontaneous emission and teleportation in cavity QED

, 2005
In this work, we consider atomic spontaneous emission in a system consisting of two identical two-level atoms interacting dispersively with the quantized electromagnetic field in a high-Q cavity.
A Vidiella-Barranco, Barnett S M, F L Semião, Gardiner C W, J A Roversi, P P Munhoz, Walls D F, Xu J B   +7 more
core   +2 more sources

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source