Results 111 to 120 of about 2,609 (289)

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Roughening dynamics of spontaneous radial imbibition

, 2015
We performed an experimental observation on the spontaneous imbibition of water in a porous media in a radial Hele-Shaw cell and confirmed Washburn's law, where r is distance and t is time. Spontaneous imbibition with a radial interface window followed scaling dynamics when the front invaded into the porous media.
Chen, Yong-Jun, Yoshikawa, Kenichi
openaire   +2 more sources

Issue Construals and Corporate Water Stewardship

Business Strategy and the Environment, EarlyView.
ABSTRACT In the face of mounting environmental and social pressures, the importance of responsible corporate water stewardship (CWS) should be evident, yet not all businesses are taking water management issues seriously. The aim of this study is to explore why differences in CWS persist, especially within industries facing similar resource challenges ...
Daina Mazutis, Mohamed Chelli, Sharon OSullivan, Katherine Hanly   +3 more
wiley   +1 more source

Modified Neumann incision for implant placement in overdentures: Case series of a less invasive alternative

Clinical Advances in Periodontics, EarlyView.
Abstract Background Conventional envelope flap techniques for implant placement in edentulous mandibles are associated with greater postoperative morbidity, especially in elderly patients or those with anatomical limitations. Minimally invasive alternatives aim to preserve soft tissues and reduce complications, enhancing clinical predictability ...
Lucas Jardim da Silva, Laura Lourenço Morel, Luciana de Rezende Pinto, Otacílio Luiz Chagas‐Júnior, Jamil Awad Shibli, Fernanda Faot   +5 more
wiley   +1 more source

A Novel Model for Pore-Scale Spontaneous Imbibition Accounting for Fluid Viscosities

, 2017
Horizontal drilling and hydraulic fracturing have been proven to significantly increase production from tight oil formations, however, one of the characteristics of these reservoirs is high production declining rate.
Zhilin Wang, Quanzheng Ma, Zhan Meng, Hao Lei, Mibang Wang, Lu Wang, Shenglai Yang, Kun Qian   +7 more
core   +1 more source

Synthesis and characterization of a highly hydrophilic nanocomposite for wettability alteration, water/oil interfacial tension reduction, and enhanced oil recovery

The Canadian Journal of Chemical Engineering, EarlyView.
Mechanism of wettability alteration, interfacial tension reduction, and oil recovery by novel nanocomposite. Abstract The development of stable nanofluids (NFs) for enhanced oil recovery (EOR) relies on optimizing interactions between reservoir rocks and fluids.
Ehsan Jafarbeigi, Ehsan Kamari, Amir H. Mohammadi   +2 more
wiley   +1 more source

Numerical Analysis of Forced and Spontaneous Imbibition of Modified-Salinity Water in Chalk

, 2020
Relative permeability and capillary pressure have a strong impact on the simulation results of fluid flow in a reservoir. In this work, the results of spontaneous imbibition experiments are added to the modelling and fitting of the relative permeability ...
Becker, H., A.A. Eftekhari, H. Becker, H. Nick, Eftekhari, A.A., Nick, H.   +5 more
core   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source