Results 21 to 30 of about 5,518 (132)
Acta Neuropathologica Communications, 2020 Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual neuron level in the MM1 and VV2 ...
Irene H. Flønes +7 more
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Diagnostic approach in a patient with Creutzfeldt-Jakob disease [PDF]
Dementia & Neuropsychologia, 2022 Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death.
José Wagner Leonel Tavares-Júnior +9 more
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Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion
Viruses, 2021 Genetic prion disease accounts for 10–15% of prion disease. While insertion of four or more octapeptide repeats are clearly pathogenic, smaller repeat insertions have an unclear pathogenicity.
Nicholas Brennecke +13 more
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The human spongiform encephalopathies [PDF]
Romanian Journal of Neurology, 2018 The human spongiform encephalopathies are a group of heterogenous, usually fatal diseases, characterized by a unique pathogenetic mechanism and distinct clinical presentation. They are classified into sporadic, familial and acquired forms.
Mavroudis Ioannis +2 more
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Frontiers in Neurology, 2018 Sporadic Creutzfeldt-Jakob disease is the most common human prion disorder. Although associated with heterogeneous clinical phenotypes, its distinctive feature is the presence of a rapidly progressive multidomain cognitive impairment.
Lorenzo Saraceno +8 more
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Annals of Clinical and Translational Neurology, 2023 Beta‐synuclein is a promising cerebrospinal fluid and blood biomarker of synaptic damage. Here we analysed its accuracy in the discrimination between sporadic Creutzfeldt–Jakob disease (n = 150) and non‐prion rapidly progressive dementias (n = 106).
Samir Abu‐Rumeileh +11 more
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Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018 Introduction Cerebrospinal fluid α‐synuclein level is increased in sporadic Creutzfeldt‐Jakob disease cases. However, the clinical value of this biomarker remains to be established.
Niels Kruse +12 more
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Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD
Annals of Clinical and Translational Neurology, 2020 Objective Real‐time quaking‐induced conversion (RT‐QuIC) assays detect prion‐seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs.
Christina D. Orrú +21 more
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Creutzfeldt–Jakob disease: A case report and differential diagnoses
Clinical Case Reports, 2022 Although sporadic Creutzfeldt–Jakob disease is a rare neurodegenerative disease and often difficult to diagnose at the earliest onset, meticulous clinical examination, electroencephalography, and neuroimaging findings will help in diagnosis.
Akash Raut +5 more
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Public health concerns regarding sporadic Creutzfeldt–Jakob disease in China: a case series
Journal of International Medical Research, 2019 In this study, we report three cases of sporadic Creutzfeldt–Jakob disease in China, two confirmed cases and one probable case. The aim of this study was to enrich the data regarding clinical and epidemiological features of this disease and to provide ...
Ru-Yi Zhou +12 more
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