Results 11 to 20 of about 11,518 (218)

Atypical Presentation of Sporadic Creutzfeldt–Jakob Disease in a 59-Year-Old Male Patient [PDF]

BJPsych Open
Aims: Creutzfeldt–Jakob Disease (CJD) is a rare, fatal neurodegenerative disorder caused by prion proteins, leading to progressive brain damage. CJD has sporadic, variant, genetic, and iatrogenic forms, with sporadic being the most common, affecting 1–2 ...
Ruzaika Jaufer
doaj   +2 more sources

Cerebrospinal Fluid Markers in Sporadic Creutzfeldt-Jakob Disease

International Journal of Molecular Sciences, 2011
Sporadic Creutzfeldt-Jakob disease (sCJD) is the commonest form of human prion diseases, accounting for about 85% of all cases. Current criteria for intra vitam diagnosis include a distinct phenotype, periodic sharp and slow-wave complexes at electroencephalography (EEG), and a positive 14-3-3-protein assay in the cerebrospinal fluid (CSF).
Gianluigi Zanusso, Michele Fiorini, Sergio Ferrari   +2 more
exaly   +4 more sources

Sporadic Creutzfeldt-Jakob disease: clinical observation

Анналы клинической и экспериментальной неврологии, 2017
Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases,fatal neurodegenerative conditions. They can be etiologicallydivided into sporadic, hereditary and acquired forms.Conformational change of the normal (cellular) form of prionprotein (PrPc)
A. V. Peresedova, N. I. Stoida, V. V. Gnezdizky, R. N. Konоvаlоv, O. S. Kоrеpina, I. A. Zavalishin   +5 more
doaj   +2 more sources

The Phenotypic Spectrum of Sporadic Creutzfeldt-Jakob Disease Cortical Subtype. [PDF]

Ann Neurol
Objective The objective of this study was to characterize the phenotypic spectrum of the rare sporadic Creutzfeldt‐Jakob disease cortical subtype (sCJDMM/MV2C) in a large multicentric autopsy cohort. Methods We evaluated clinical histories, biofluid markers, brain diffusion‐weighted (DW)‐magnetic resonance imaging (MRI), and electroencephalogram (EEG ...
Baiardi S, Vargiu CM, Appleby BS, Barria M, Bentivenga GM, Calì I, Carlà B, Cohen M, Giese A, Herms J, Kortelainen AM, Ladogana A, Mammana A, Ritchie D, Windl O, Capellari S, Parchi P.   +16 more
europepmc   +2 more sources

Chorea in Sporadic Creutzfeldt-Jakob Disease [PDF]

Journal of Movement Disorders, 2018
Ai Huey Tan, Tsun Haw Toh, Soon Chai Low, Si Lei Fong, Kah Kian Chong, Kee Wei Lee, Khean Jin Goh, Shen-Yang Lim   +7 more
doaj   +3 more sources

The First Sporadic Creutzfeldt–Jakob Disease Case with a Rare Molecular Subtype VV1 and 1-Octapeptide Repeat Deletion in PRNP

Viruses, 2021
In the present manuscript, we report the clinical presentation and challenging diagnostic work-up of a sporadic Creutzfeldt–Jakob disease patient with confirmed VV1 subtype and heterozygous 1-octapeptide repeat deletion in the prion protein gene.
Aušrinė Areškevičiūtė, Eva Løbner Lund, Sabina Capellari, Piero Parchi, Christian Tersbøl Pinkowsky   +4 more
doaj   +1 more source

Sporadic Creutzfeldt-Jakob Disease Mimicking Variant Creutzfeldt-Jakob Disease [PDF]

Archives of Neurology, 2003
The determination of the form of prion disease and early diagnosis are important for prognostic, public health, and epidemiologic reasons.To describe a patient with sporadic Creutzfeldt-Jakob disease (sCJD) who had a clinical history and initial electroencephalogram and magnetic resonance imaging findings consistent with variant CJD (vCJD).Results of a
Jennifer, Martindale, Michael D, Geschwind, Stephen, De Armond, Geoffrey, Young, W P, Dillon, Roland, Henry, Jane H, Uyehara-Lock, David A, Gaskin, Bruce L, Miller   +8 more
openaire   +2 more sources

Long survival sporadic Creutzfeldt-Jakob disease [PDF]

Neurology, 2020
A 63-year-old woman had slowly progressive dementia. EEG displayed periodic sharp wave complexes. MRI showed cortical ribbon pattern in cortex and hyperintensity in basal ganglia (figure, A–H). Genetics testing confirmed homozygosity for methionine at the polymorphic codon 129 of the PRNP gene.
Xiao-Ying Liu, Qi Shi, Gang Wang
openaire   +2 more sources

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Acta Neuropathologica Communications, 2020
Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual neuron level in the MM1 and VV2 ...
Irene H. Flønes, Gerda Ricken, Sigrid Klotz, Alexandra Lang, Thomas Ströbel, Christian Dölle, Gabor G. Kovacs, Charalampos Tzoulis   +7 more
doaj   +1 more source

Diagnostic approach in a patient with Creutzfeldt-Jakob disease [PDF]

Dementia & Neuropsychologia, 2022
Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death.
José Wagner Leonel Tavares-Júnior, Renata de Oliveira Carvalho, Raul Raposo Pereira Feitosa, Flávia de Paiva Santos Rolim, Felipe Araújo Rocha, Milena Sales Pitombeira, George Linard Silva Malveira, João José Freitas de Carvalho, Norberto Anizio Ferreira Frota, Daniel Aguiar Dias   +9 more
doaj   +1 more source