Results 41 to 50 of about 11,518 (218)

Young-onset sporadic Creutzfeldt–Jakob disease with atypical phenotypic features: a case report

Journal of Medical Case Reports, 2019
Background Sporadic Creutzfeldt–Jakob disease, with a mean survival of 6 months, is duly considered among the most fatal neurological disorders. Rapidly progressive dementia with multi-axial involvement of the nervous system is the known presentation ...
Durjoy Lahiri, Srimant Pattnaik, Ashwani Bhat, Souvik Dubey, Atanu Biswas, Biman Kanti Roy   +5 more
doaj   +1 more source

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]

, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
A Birgersdotter, Anastasia C. Hepburn, AS Goldstein, AT Collins, AT Collins, C Cai, C Lin, CD Chen, CJ Shepherd, Claudia A. Ryan-Munden, CM van der Loos, Craig N. Robson, D Corbeil, DA Lawson, Deepali Pal, DJ Vander Griend, DM Owens, DT Ross, G Attard, G Buchanan, GD Richardson, GR Cunha, H Bonkhoff, H Bonkhoff, Hing Y. Leung, IV Litvinov, J Perez-Losada, J Yu, JA Kemppainen, JK Blackwood, Kelly Coffey, KG Leong, KM Bae, L Patrawala, Laura Wilson, LE Lamb, MC Haffner, N Platet, NT Gaisa, R Heer, R Heer, Rakesh Heer, S Kolli, S Mousses, SO Lee, Stuart C. Williamson, VK Rajasekhar, X Wang, Yao Liang Tang   +48 more
core   +4 more sources

Sporadic Creutzfeldt–Jakob disease

, 2018
Sporadic Creutzfeldt-Jakob disease (CJD), the most common human prion disease, is generally regarded as a spontaneous neurodegenerative illness, arising either from a spontaneous PRNP somatic mutation or a stochastic PrP structural change. Alternatively, the possibility of an infection from animals or other source remains to be completely ruled out ...
Zerr, Inga, Parchi, Piero
openaire   +4 more sources

Rapidly Progressive Probable Sporadic Creutzfeldt-Jakob Disease

Cureus, 2022
Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain infection caused by a human prion. Because CJD is associated with rapidly progressive neurological degeneration, it requires high suspicion for diagnosis. We report the case of a 79-year-old patient who presented with a rapidly progressive neurological clinical picture.
Elziny, Moustafa M, Elsaid, Shaimaa S
openaire   +2 more sources

Applicability of long-term electroencephalography in pre-mortem diagnosis of Creutzfeldt–Jakob disease: A case report

SAGE Open Medical Case Reports, 2017
Creutzfeldt–Jakob disease accounts for more than 90% of all sporadic prion disease cases. The molecular MM2 genotype has been divided into cortical and thalamic subtypes based on structures involved and is characterized clinically by progressive dementia
Sanaz Attaripour Isfahani, Michelle Dougherty, Gediminas Peter Gliebus   +2 more
doaj   +1 more source

Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias:a longitudinal multicentre study over 10 years [PDF]

, 2012
To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt–Jakob disease cases.
Aguzzi, Adriano, Calero, Miguel, Gawinecka, Joanna, Green, Alison, Karch, Andre, Knight, Richard, Kulczycki, Jerzy, Ladogana, Anna, Laplanche, Jean-Louis, Mitrova, Eva, Peoc'h, Katell, Pocchiari, Maurizio, Saiz, Albert, Sanchez-Juan, Pascual, Sanchez-Valle, Raquel, Schelzke, Gabi, Sklaviadis, Theodor, Slivarichova, Dana, Stoeck, Katharina, van Duijn, Cornelia M., Zerr, Inga   +20 more
core   +1 more source

Sporadic Creutzfeldt-Jakob disease in Northern Tasmania

Journal of the Royal College of Physicians of Edinburgh, 2023
Creutzfeldt-Jakob disease is a rare and incurable form of rapidly progressive neurodegenerative disease. The disease is fatal, and most patients die within 1 year of diagnosis. Clinical features include progressive cognitive dysfunction, delusions or hallucinations, cerebellar ataxia, myoclonus, visual disturbances, extrapyramidal signs and eventually
Priyanka Rajalingam, Aaron de Souza, Matthew Lee-Archer, Mahesh Dhakal   +3 more
openaire   +2 more sources

Symptomatic nonconvulsive status epilepticus erroneously suggestive of sporadic Creutzfeldt-Jakob disease [PDF]

, 2015
Nonconvulsive status epilepticus (NCSE) may have heterogeneous presentations and differential diagnosis may be particularly difficult because clinical signs coupled with periodic EEG pattern are most often subtle or non-specific.
Albanese, M, Floris, R, Garaci, F, Izzi, F, Liguori, C, Marchi, A, Marciani, M, Mercuri, N, Placidi, F, Romigi, A, Schirinzi, T   +10 more
core   +1 more source

Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease [PDF]

, 2006
To validate the provisional findings of a number of smaller studies and explore additional determinants of characteristic diagnostic investigation results across the entire clinical spectrum of sporadic Creutzfeldt-Jakob disease (CJD), an international ...
Almonti, S. (S.), Alperovitch, A. (Annick), Brandel, J-P. (Jean-Philippe), Budka, H. (Herbert), Collins, S.J. (Steven), Cuadrado-Corrales, N. (Natividad), Duijn, C.M. (Cornelia) van, Gelpi, E. (Ellen), Glatzel, M. (Markus), Heinemann, U., Hewer, E., Jansen, G.H. (Gerard), Klug, G.M. (Genevieve), Kretszchmar, H.A. (Hans), Mackenzie, J., Masters, C. (Colin), Mitrova, E. (E.), Murray, K. (K.), Olsen, E. (E.), Pedro-Cuesta, J. (Jesús) de, Pocchiari, M. (Maurizio), Poleggi, A. (Anna), Sanchez-Juan, P. (Pascual), Tolnay, M. (Markus), Will, R.G. (Robert), Zerr, I. (Inga)   +25 more
core   +1 more source

Movement Disorders in Prionopathies: A Systematic Review

Tremor and Other Hyperkinetic Movements, 2019
Background: Movement disorders are frequent features of prionopathies. However, their prevalence and onset remain poorly described. Methods: We performed a systematic review of case reports and case series of pathologically- and genetically confirmed ...
Federico Rodriguez-Porcel, Vinícius Boaratti Ciarlariello, Alok K. Dwivedi, Lilia Lovera, Gustavo Da Prat, Ricardo Lopez-Castellanos, Ritika Suri, Holly Laub, Ruth H. Walker, Orlando Barsottini, José Luiz Pedroso, Alberto J. Espay   +11 more
doaj   +1 more source