Results 51 to 60 of about 5,084,169 (167)

Risk Ranking of Microbiological Hazards in Food (2015–2019)

Food Risk Assess Europe, Volume 4, Issue 3, July 2026.
Abstract Microbiological food safety risks arise from pathogens that can contaminate food at different points along the food chain. Exposure to these hazards can result in illnesses that can vary widely in severity and duration, depending on factors such as the specific pathogen involved, the amount of the pathogen ingested, and the susceptibility of ...
Ms Chloe Glennon, Lisa O’Connor, Kevin Burke, Lauren Russell, Shaun Smith, Declan Bolton, Theo de Waal, Patricia Garvey, Montserrat Gutierrez, Noel McCarthy, Lois O’Connor, Helen O’Shea, Geraldine Duffy   +12 more
wiley   +1 more source

A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis

Nature Communications, 2020
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from ...
Penny J. Norsworthy, Andrew G. B. Thompson, Tze H. Mok, Fernando Guntoro, Luke C. Dabin, Akin Nihat, Ross W. Paterson, Jonathan M. Schott, John Collinge, Simon Mead, Emmanuelle A. Viré   +10 more
doaj   +1 more source

HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone, Eleonora Busani, Roberto Chiesa   +2 more
wiley   +1 more source

Sporadic Creutzfeldt–Jakob Disease

Acta Medica Bulgarica
Sporadic Creutzfeldt–Jakob disease is a rare and fatal human prion disease characterized by a rapidly progressive dementia, myoclonus, cerebellar, pyramidal, extrapyramidal, visual, and psychiatric symptoms. These findings are all non-specific and making
Zhelyazkova S., Nachev S., Kalev O., Tournev I.   +3 more
doaj   +1 more source

Sporadic Creutzfeldt-Jakob disease: clinical observation

Анналы клинической и экспериментальной неврологии, 2017
Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases,fatal neurodegenerative conditions. They can be etiologicallydivided into sporadic, hereditary and acquired forms.Conformational change of the normal (cellular) form of prionprotein (PrPc)
A. V. Peresedova, N. I. Stoida, V. V. Gnezdizky, R. N. Konоvаlоv, O. S. Kоrеpina, I. A. Zavalishin   +5 more
doaj   +1 more source

Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease

Communications Biology, 2021
Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease.
Lesley Cheng, Camelia Quek, Xia Li, Shayne A. Bellingham, Laura J. Ellett, Mitch Shambrook, Saima Zafar, Inga Zerr, Victoria A. Lawson, Andrew F. Hill   +9 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

White matter involvement in sporadic Creutzfeldt-Jakob disease [PDF]

, 2014
Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter, although the extent of white matter involvement has not been well described.
DeArmond, Stephen J, Vitali, Paolo, Papinutto, Nico, Mandelli, Maria Luisa, Henry, Roland G, Oehler, Abby, Geschwind, Michael D, Hess, Christopher P, Caverzasi, Eduardo, Lobach, Irina V, Miller, Bruce L, Bastianello, Stefano   +11 more
core   +2 more sources

Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt–Jakob Disease

Frontiers in Neurology, 2020
Objectives: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and sporadic Creutzfeldt–Jakob disease (sCJD) share similar clinical features. Here, we present two unusual cases of anti-NMDAR encephalitis who were misdiagnosed as sCJD at first ...
Jiao Liu, Liyan Chen, Jing Yang, Lan Wang, Huifang Shang, Xueping Chen   +5 more
doaj   +1 more source

Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993–2002

BMC Public Health, 2006
Background The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. Methods From data collected for surveillance purposes, we describe annual proportions of deaths due to ...
Jansen Gerard H, Lewis Victoria, Collins Steven, Sanchez-Juan Pascual, Van Duijn Cornelia, Alpérovitch Annick, Delasnerie-Lauprêtre Nicole, Brandel Jean-Philippe, Kretszchmar Hans A, Zerr Inga, Pocchiari Maurizio, Puopolo Maria, Mellina Vittorio, Stoeck Katharina, Almazán Javier, Glatzel Markus, de Pedro-Cuesta Jesús, Coulthart Michael B, Gelpi Ellen, Budka Herbert, Mitrova Eva   +20 more
doaj   +1 more source