Results 71 to 80 of about 11,518 (218)

A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis

Nature Communications, 2020
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from ...
Penny J. Norsworthy, Andrew G. B. Thompson, Tze H. Mok, Fernando Guntoro, Luke C. Dabin, Akin Nihat, Ross W. Paterson, Jonathan M. Schott, John Collinge, Simon Mead, Emmanuelle A. Viré   +10 more
doaj   +1 more source

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression [PDF]

, 2018
OBJECTIVES: A blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies.
Collinge, J, Heslegrave, AJ, Jackson, GS, Luk, C, Mead, SH, Thompson, AGB, Zetterberg, H   +6 more
core   +1 more source

Structural signature of sporadic Creutzfeldt–Jakob disease

European Journal of Neurology, 2019
Background and purposeSporadic Creutzfeldt–Jakob disease (sCJD) is a rapidly progressive neurodegenerative disease caused by an abnormal isoform of the human prion protein. Structural magnetic resonance imaging in patients with pathologically confirmed sCJD was compared with cognitively normal individuals to identify a cortical thickness signature of ...
J. Navid, G. S. Day, J. Strain, R. J. Perrin, R. C. Bucelli, A. Dincer, J. K. Wisch, D. Soleimani‐Meigooni, J. C. Morris, T. L. S. Benzinger, B. M. Ances   +10 more
openaire   +6 more sources

Neuroprotection trial design in progressive supranuclear palsy: challenges and solutions

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION We review the specific challenges posed to neuroprotective trial design by progressive supranuclear palsy (PSP), a rare disorder difficult to diagnose and to assess quantitatively. METHODS Focusing on reducing the size and cost of trials, we review elements of PSP neuroprotection trial methodology and formulate a new minimum ...
Lawrence I. Golbe, Ronald G. Thomas
wiley   +1 more source

Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt‐Jakob disease

Clinical Case Reports, 2021
Sporadic Creutzfeldt‐Jakob disease should be considered in any case of rapid neuropsychiatric decline. While neuropathological examination of a brain biopsy specimen remains the only definitive diagnostic method and real‐time quaking‐induced conversion ...
Elina T Ziukelis, Vasu Keshav Sharma, James J Gome   +2 more
doaj   +1 more source

Transmission of scrapie prions to primate after an extended silent incubation period [PDF]

, 2015
Citation: Comoy, E. E., Mikol, J., Luccantoni-Freire, S., Correia, E., Lescoutra-Etchegaray, N., Durand, V., . . . Deslys, J. P. (2015). Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports, 5.
Andreoletti, O., Baron, T., Benestad, S. L., Brown, P., Casalone, C., Comoy, E. E., Correia, E., Dehen, C., Deslys, J. P., Durand, V., Greenlee, J. J., Lescoutra-Etchegaray, N., Luccantoni-Freire, S., Mikol, J., Richt, Juergen A.   +14 more
core   +3 more sources

Possible alignment of the EU BSE surveillance with the new WOAH provisions

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The European Commission requested the assessment of the capacity of the surveillance provisions of the World Organization for Animal Health (WOAH) to detect bovine spongiform encephalopathy (BSE) cases (C‐, H‐ and L‐type) in the European Union (EU) and to propose if any current EU surveillance provisions should be kept.
EFSA Panel on Animal Health and Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Angel Miranda Chueca, Eleonora Nannoni, Anja B. Riber, Karl Stahl, Jan Arend Stegeman, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Mark Arnold, Christian Ducrot, John Griffin, Giuseppe Ru, Marion Simmons, Sean Ashe, Angel Ortiz‐ Pelaez, Kamela Kryemadhi, Romolo Nonno   +25 more
wiley   +1 more source

Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993–2002

BMC Public Health, 2006
Background The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. Methods From data collected for surveillance purposes, we describe annual proportions of deaths due to ...
Jansen Gerard H, Lewis Victoria, Collins Steven, Sanchez-Juan Pascual, Van Duijn Cornelia, Alpérovitch Annick, Delasnerie-Lauprêtre Nicole, Brandel Jean-Philippe, Kretszchmar Hans A, Zerr Inga, Pocchiari Maurizio, Puopolo Maria, Mellina Vittorio, Stoeck Katharina, Almazán Javier, Glatzel Markus, de Pedro-Cuesta Jesús, Coulthart Michael B, Gelpi Ellen, Budka Herbert, Mitrova Eva   +20 more
doaj   +1 more source

Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt–Jakob Disease

Frontiers in Neurology, 2020
Objectives: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and sporadic Creutzfeldt–Jakob disease (sCJD) share similar clinical features. Here, we present two unusual cases of anti-NMDAR encephalitis who were misdiagnosed as sCJD at first ...
Jiao Liu, Liyan Chen, Jing Yang, Lan Wang, Huifang Shang, Xueping Chen   +5 more
doaj   +1 more source

Is sporadic Creutzfeldt‐Jakob disease transfusion‐transmissible? [PDF]

Transfusion, 2020
See article on page 694–697, in this ...
openaire   +2 more sources