Results 81 to 90 of about 11,518 (218)

Selective vulnerability to atrophy in sporadic Creutzfeldt‐Jakob disease

Annals of Clinical and Translational Neurology, 2021
Objective Identification of brain regions susceptible to quantifiable atrophy in sporadic Creutzfeldt‐Jakob disease (sCJD) should allow for improved understanding of disease pathophysiology and development of structural biomarkers that might be useful in
Kyan Younes, Julio C. Rojas, Amy Wolf, Goh M. Sheng‐Yang, Matteo Paoletti, Gianina Toller, Eduardo Caverzasi, Maria Luisa Mandelli, Ignacio Illán‐Gala, Joel H. Kramer, Yann Cobigo, Bruce L. Miller, Howard J. Rosen, Michael D. Geschwind   +13 more
doaj   +1 more source

Strain Traits of Intracranially Administered L‐Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys

Microbiology and Immunology, Volume 70, Issue 3, Page 166-174, March 2026.
ABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Ken'ichi Hagiwara, Hiroaki Shibata, Minoru Tobiume, Yuko Sato, Keiko Ohto, Sachi Okabayashi, Nozomi Nakano, Motohiro Horiuchi, Fumiko Ono   +8 more
wiley   +1 more source

Sporadic Creutzfeldt-Jakob disease: Clinical, pathological and molecular study [PDF]

Revista Ciencias de la Salud, 2008
phalopathiesare neurodegenerative diseasescaused by abnormal accumulation of pathogenicisoform the prion protein, which induces theformation of conglomerates protein resistantto degradation.
Victoria Eugenia Villegas, Fernando Velandia, Cesar Payán   +2 more
doaj  

A case of probable sporadic Creutzfeldt–Jakob disease

Family Medicine and Community Health, 2017
Creutzfeldt-Jakob Disease (CJD) is a fatal neurodegenerative brain disease. The author describes a case presented to primary care clinic whereby neuropsychiatric symptoms were the patient’s initial presentation which later manifested with declining ...
Norita Hussein
doaj   +1 more source

Dental treatment and risk of variant CJD - a case control study [PDF]

, 2007
Objective: Knowledge of risk factors for variant CJD (vCJD) remains limited, but transmission of prion proteins via re-useable medical devices, including dental instruments, or enhanced susceptibility following trauma to the oral cavity is a concern ...
A. J. Smith, AH Lowe, AH Peden, AJ Smith, CA Llewelyn, CM Van Duijn, D. Everington, ER Mulcahy, F Blanquet-Grossard, H. J. T. Ward, HJT Ward, HJT Ward, J. Bagg, JC Bartz, K Kondo, L Ingrosso, MW Head, R. G. Will, RG Will, S Collins, S. Letters, Z Davinpour   +21 more
core   +1 more source

Epilepsia partialis continua as the presenting manifestation of Creutzfeldt–Jakob disease: A video‐polygraphic clinical vignette

Epileptic Disorders, EarlyView.
Roberta Cutellè, Angelo Pascarella, Ada Santoro, Vittoria Cianci, Anna Mammì, Giovanbattista Gaspare Tripodi, Caterina Prestandrea, Sara Gasparini, Edoardo Ferlazzo   +8 more
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP [PDF]

, 2009
Stop codon mutations in the gene encoding the prion protein (PRNP) are very rare and have thus far only been described in two patients with prion protein cerebral amyloid angiopathy (PrP-CAA).
Casper Jansen, Piero Parchi, Sabina Capellari, Ad J. Vermeij, Patrizia Corrado, Frank Baas, Rosaria Strammiello, Willem A. van Gool, John C. van Swieten, Annemieke J. M. Rozemuller, H Braak, V Campana, S Capellari, S Capellari, B Chesebro, U Finckh, P Gambetti, B Ghetti, B Ghetti, B Ghetti, B Ghetti, G Giaccone, F Gray, C Haass, J Hardy, SI Ikeda, JW Ironside, C Keohane, GR Mallucci, M Mohr, R Nitrini, S Notari, C Paquet, P Parchi, P Parchi, P Piccardo, T Revesz, F Tagliavini, J Tateishi, DR Thal, HV Vinters, S Vogelgesang, J Woulfe, M Yamada   +43 more
core   +9 more sources

High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease [PDF]

, 2011
Background The gamma-isoform of the 14-3-3 protein (14-3-3 gamma) is expressed in neurons, and could be a specific marker for neuronal damage.
Yuki Matsui, Katsuya Satoh, Toshiaki Miyazaki, Susumu Shirabe, Ryuichiro Atarashi, Kazuo Mutsukura, Akira Satoh, Yasufumi Kataoka, Noriyuki Nishida   +8 more
core   +1 more source

Association of genetic predisposition to dyslipidemia and physical activity with incident dementia

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The association between genetic predisposition to dyslipidemia and dementia risk is inconsistent. It remains unknown whether a physically active lifestyle is associated with a lower dementia risk across different levels of this genetic predisposition.
Yumei Liang, Siqi Xie, Dandan Sheng, Lan Ding, Ting Yang, Jianping Jia   +5 more
wiley   +1 more source