Results 101 to 110 of about 11,518 (218)

Inflammatory Cerebrospinal Fluid in Sporadic Creutzfeldt-Jakob Disease [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2008
Background:Sporadic Creutzfeldt-Jakob disease (CJD) is a fatal, transmissible spongiform encephalopathy characterized by rapidly progressive dementia, myoclonus, ataxia and akinetic mutism. The underlying mechanism is believed to be a conformational change of a native prion protein which characteristically fails to provoke an immune response ...
Esther, Bui, Eric, Ehrensperger, Demetrios J, Sahlas, Brian J, Murray, Catherine, Bergeron, Rafael S, Glikstein, Richard, Aviv, Hyman M, Schipper   +7 more
openaire   +2 more sources

Prodromal Sleep Disturbances and Polysomnographic Findings in Patients With Creutzfeldt–Jakob Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study investigates the sleep‐related manifestations of Creutzfeldt–Jakob disease (CJD) by analyzing electroencephalography (EEG) and polysomnography (PSG) findings in a cohort of seven patients diagnosed between 2013 and 2023. Although only three patients initially reported sleep‐related complaints, comprehensive assessments revealed that all ...
Ezgi Demirel, Gul Yalcin‐Cakmakli, Ezgi Yetim, Serap Saygi, Fadime Irsel Tezer   +4 more
wiley   +1 more source

Quantitative EEG parameters correlate with the progression of human prion diseases [PDF]

, 2016
BACKGROUND: Prion diseases are universally fatal and often rapidly progressive neurodegenerative diseases. EEG has long been used in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic waveforms do not occur in all types of ...
Collinge, J, Franko, E, Joly, O, Kenny, J, Lowe, J, Mead, S, Porter, MC, Rudge, P, Thompson, A, Wehner, T   +9 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years [PDF]

, 2017
To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt-Jakob disease cases.
Aguzzi, Adriano, Calero, Miguel, Gawinecka, Joanna, Green, Alison, Karch, Andre, Knight, Richard, Kulczycki, Jerzy, Ladogana, Anna, Laplanche, Jean-Louis, Mitrova, Eva, Peoc'h, Katell, Pocchiari, Maurizio, Saiz, Albert, Sanchez-Juan, Pascual, Sanchez-Valle, Raquel, Schelzke, Gabi, Sklaviadis, Theodor, Slivarichova, Dana, Stoeck, Katharina, van Duijn, Cornelia M., Zerr, Inga   +20 more
core  

Pathologically confirmed autoimmune encephalitis in suspected Creutzfeldt-Jakob disease [PDF]

, 2015
Objective: To determine the clinical features and presence in CSF of antineuronal antibodies in patients with pathologically proven autoimmune encephalitis derived from a cohort of patients with suspected Creutzfeldt-Jakob disease (CJD).
Beukelaar, J.W.K. (Janet) de, Duijn, C.M. (Cornelia) van, Graaff, E. (Esther) de, Jansen, C. (Casper), Maat, P. (Peter), Rozemuller, A.J.M. (Annemieke), Schuur, M. (Maaike), Smitt, P.S., Titulaer, M.J. (Maarten), Van Coevorden, M.H. (Marleen H.)   +9 more
core   +1 more source

Sporadic Creutzfeldt-Jakob Disease

Türk Nöroloji Dergisi, 2013
Abstract Not ...
Degirmenci, E., Degirmenci, T., Erdogan, Ç., Aras, D., Kiroglu, Y., Oguzhanoglu, A.   +5 more
openaire   +2 more sources

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50%

European Journal of Neurology, Volume 32, Issue 12, December 2025.
This study investigated whether transmission ratio distortion (TRD) occurs in inherited prion diseases, specifically familial Creutzfeldt‐Jakob disease (p.E200K variant) and fatal familial insomnia (p.D178N variant), despite the theoretical 50% autosomal dominant inheritance risk.
Izaro Kortazar‐Zubizarreta, Africa Manero‐Azua, Hasier Eraña, Urko Aguire, Joaquín Castilla, Guiomar Perez de Nanclares   +5 more
wiley   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, Volume 5, Issue 11, November 2025.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Transmission of CJD from nasal brushings but not spinal fluid or RT‐QuIC product

Annals of Clinical and Translational Neurology, 2020
Objective The detection of prion seeding activity in CSF and olfactory mucosal brushings using real‐time quaking‐induced conversion assays allows highly accurate clinical diagnosis of sporadic Creutzfeldt–Jakob disease.
Gregory J. Raymond, Brent Race, Christina D. Orrú, Lynne D. Raymond, Matilde Bongianni, Michele Fiorini, Bradley R. Groveman, Sergio Ferrari, Luca Sacchetto, Andrew G. Hughson, Salvatore Monaco, Maurizio Pocchiari, Gianluigi Zanusso, Byron Caughey   +13 more
doaj   +1 more source