Results 121 to 130 of about 11,518 (218)

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer [PDF]

, 2002
Up to 15% of free-ranging mule deer in northeastern Colorado and southeastern Wyoming, USA, are afflicted with a prion disease, or transmissible spongiform encephalopathy (TSE), known as chronic wasting disease (CWD).
Barillas-Mury, C., Hoover, E.A., Keulen, L.J.M., van, Langeveld, J.P.M., Miller, M.W., Oesch, B., Sigurdson, C.J.   +6 more
core   +2 more sources

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease [PDF]

, 2013
Blood transfusion has been identified as a source of human-to-human transmission of variant Creutzfeldt–Jakob disease. Three cases of variant Creutzfeldt–Jakob disease have been identified following red cell transfusions from donors who subsequently ...
Abigail B. Diack, Bishop, Brown, Bruce, Bruce, Bruce, Clarke, Diack, Diane L. Ritchie, Fraser, Garske, Head, Hill, Hilton, HPA, James W. Ironside, Jean C. Manson, Llewelyn, Matthew T. Bishop, Peden, Pocchiari, Prusiner, Ritchie, Robert G. Will, Wadsworth, Will, Wroe   +26 more
core   +1 more source

Novel mutation of the PRNPgene of a clinical CJD case [PDF]

, 2006
Background Transmissible spongiform encephalopathies (TSEs), a group of neurodegenerative diseases, are thought to be caused by an abnormal isoform of a naturally occurring protein known as cellular prion protein, PrPC. The abnormal form of prion protein,
Konstantia Kotta, Ioannis Paspaltsis, Sevasti Bostantjopoulou, Helen Latsoudis, Andreas Plaitakis, Dimitrios Kazis, John Collinge, Theodoros Sklaviadis, SB Prusiner, H Bueler, P Parchi, K Peoc'h, C Tranchant, JP Brandel, SB Prusiner, SB Prusiner, GG Kovacs, GG Kovacs, A Ladogana, J Wiltfang, WHO, I Zerr, R Sanchez-Valle, MS Palmer, A Plaitakis, AA Saetta, T van Rheede, R Zahn, S Collins, K Peoc'h   +29 more
core   +2 more sources

Detection of Creutzfeldt-Jakob disease prions in skin: implications for healthcare

Genome Medicine, 2018
Editorial summary Evidence has recently been reported of prion seeding activity in skin tissue from patients with sporadic Creutzfeldt-Jakob disease (sCJD). This is relevant information for infection control measures during surgery.
Akin Nihat, Simon Mead
doaj   +1 more source

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]

, 2010
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A., Jacobs, J.G., Keulen, L.J.M., van, Langeveld, J.P.M., Sauer, M., Tang, Y.   +5 more
core   +2 more sources

Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease

Emerging Infectious Diseases, 2012
We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein–transgenic mouse line and isolated distinct prion
Simon Nicot, Anna Bencsik, Eric Morignat, Nadine Mestre-Francés, Armand Perret-Liaudet, Thierry Baron   +5 more
doaj   +1 more source

Neuroimagen estructural y funcional en las enfermedades priónicas humanas [PDF]

, 2011
INTRODUCTION: Prion diseases are neurodegenerative disorders resulting from the accumulation of a misfolded isoform of the cellular prion protein (PrPc). They can occur as acquired, sporadic or hereditary forms. Although prion diseases show a wide range
Arbizu, J. (Javier), Carmona-Abellan, M. (M.), Dominguez-Prado, I. (Inés), Luquin, M.R. (María Rosario), Ortega-Cubero, S. (Sara), Pagola, I. (I.), Riverol, M. (Mario)   +6 more
core  

Cross currents in protein misfolding disorders: interactions and therapy. [PDF]

, 2009
Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues involved, PMDs share similar molecular and pathogenic mechanisms.
Green, Kristi M, Morales, Rodrigo, Soto, Claudio   +2 more
core   +1 more source

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. [PDF]

, 2017
Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades.
Alibhai, James, Chandran, Siddharthan, Head, Mark W, Ironside, James W, Krejciova, Zuzana, Krencik, Robert, Manson, Jean, Rzechorzek, Nina M, Ullian, Erik M, Zhao, Chen   +9 more
core   +1 more source

Sporadic cjd and retinitis punctata albescansa case report and literature review [PDF]

, 2014
Introduction Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of CJD causing 85% of all cases. Various phenotypes of sCJD have been identified including Heidenhain variant which has early and predominant visual symptoms with most ...
Hanif Khan, Yusra, Khan, Quratulain
core   +1 more source