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Mitochondrial DNA depletion in sporadic inclusion body myositis [PDF]

Neuromuscular Disorders, 2019
Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial DNA (mtDNA) deletions have also been reported, but not consistently.
Novin Balafkan, Hrvoje Miletic, Padmanabh Bhatt   +2 more
exaly   +5 more sources

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Sporadic Inclusion Body Myositis

2008
Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease in elderly individuals, particularly men. Its prevalence varies among ethnic groups, but it is estimated at 35 per one million people over 50 years. Genetic as well as environmental factors and autoimmune processes might both have a role in its pathogenesis. Unlike other
Josep M. Grau, Albert Selva-O’Callaghan   +1 more
openaire   +1 more source

Genetic advances in sporadic inclusion body myositis

Current Opinion in Rheumatology, 2015
To describe recent developments in the genetics of sporadic inclusion body myositis (sIBM).Genes located within major histocompatibility complex regions remain the strongest genetic association with sIBM. The rs10527454 polymorphism in the TOMM40 gene seems to have a disease modifying effect on sIBM by delaying the onset of symptoms, and this effect ...
Qiang, Gang, Conceição, Bettencourt, Henry, Houlden, Michael G, Hanna, Pedro M, Machado   +4 more
openaire   +2 more sources

ANT1 is reduced in sporadic inclusion body myositis

Neurological Sciences, 2012
To investigate ANT1 and NF-κB expression in inclusion body myositis (IBM) muscle and to verify their possible roles in the pathogenesis of the disease, we collected muscle samples from five patients with IBM, polimyositis (PM) and controls. p65 form of NF-κB was analyzed using immunocytochemistry, Western blot and EMSA.
BARCA, EMANUELE, AGUENNOUZ, M'hammed, MAZZEO, Anna, MESSINA, Sonia, TOSCANO, Antonio, VITA, GIANLUCA, PORTARO, SIMONA, PARISI, DANIELA, RODOLICO, Carmelo   +8 more
openaire   +2 more sources

Sporadic inclusion body myositis: a continuing puzzle

Neuromuscular Disorders, 2008
There is now compelling evidence that sporadic inclusion body myositis (sIBM) is a muscle-specific autoimmune disease in which both T and B-cells play a part and in which both cytotoxic muscle fibre necrosis and degeneration occur. However the factors responsible for breakdown of immune tolerance and the nature of the target antigens expressed by ...
Needham, M., Mastaglia, F.L.
openaire   +2 more sources

McArdle disease and sporadic inclusion body myositis

Neuropathology and Applied Neurobiology, 2009
No abstract ...
Scarpelli M., Vattemi G., Filosto M., Krause S., Marini M., Tomelleri G., Tonin P.   +6 more
openaire   +2 more sources

Electromyographic findings in sporadic inclusion body myositis

Journal of Electromyography and Kinesiology, 2018
Clinically oriented diagnostic criteria can be as specific for diagnosis of sporadic inclusion body myositis (sIBM) as pathological criteria, especially at the time of presentation. EMG may provide an convincing proof that a muscle biopsy should be performed.To compare the EMG results in patients with sIBM divided into subgroups based on the newest ...
Monika Magdalena Nojszewska, Małgorzata Gaweł, Biruta Kierdaszuk, Janusz Sierdziński, Elżbieta Szmidt-Sałkowska, Andrzej Seroka, Anna Maria Kamińska, Anna Agnieszka Kostera-Pruszczyk   +7 more
openaire   +2 more sources

Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis

Neurobiology of Aging, 2016
Hector Chinoy, Merrilee Needham, Stefen Brady   +2 more
exaly   +2 more sources

Sporadic inclusion body myositis: Pathogenic considerations

Annals of Neurology, 2009
AbstractSporadic inclusion body myositis is the commonest acquired disease of skeletal muscles after 50 years of age, and as such it has commanded a great deal of attention of investigators over the past 25 years. As a result, a large amount of information has accumulated concerning its clinical profile, myopathology, and immunopathology.
George, Karpati, Erin K, O'Ferrall
openaire   +2 more sources

Controlling autoimmunity in sporadic inclusion-body myositis

Neurology, 2006
Sporadic inclusion-body myositis (s-IBM) spans two areas of interest in my research lab, the role of protein aggregation in neurodegenerative disease1–4 and the role of secondary autoimmunity in degenerative conditions in the nervous system5–10 and in muscle.11,12 After some comments on the potential pathologic role of inclusion bodies themselves, I ...
openaire   +2 more sources