Results 71 to 80 of about 2,106 (149)

Foxo/Atrogin induction in human and experimental myositis

Neurobiology of Disease, 2012
Skeletal muscle atrophy can occur rapidly in various fasting, cancerous, systemic inflammatory, deranged metabolic or neurogenic states. The ubiquitin ligase Atrogin-1 (MAFbx) is induced in animal models of these conditions, causing excessive myoprotein ...
Han-Kyu Lee, Edward Rocnik, Qinghao Fu, Bumsup Kwon, Ling Zeng, Kenneth Walsh, Henry Querfurth   +6 more
doaj   +1 more source

Use of Janus Kinase Inhibitors in the Treatment of Genodermatoses: A Systematic Review

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Introduction Genodermatoses are rare inherited skin disorders with limited treatment options. Emerging evidence suggests Janus kinase (JAK) inhibitors may offer therapeutic benefits by modulating underlying immune and inflammatory pathways. This study aims to systematically review the efficacy and safety of JAK inhibitors in treating genodermatoses ...
Pin-Chun Chen, Chih-Chiang Chen, Sheng-Hsiang Ma, Tai-Li Chen, Suraiya Saleem   +4 more
wiley   +1 more source

The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy

Clinical and Developmental Immunology, 2012
The idiopathic inflammatory myopathies (IM) represent a heterogeneous group of autoimmune diseases, of which dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM) are the most common.
Boel De Paepe, Kim K. Creus, Jan L. De Bleecker   +2 more
doaj   +1 more source

Risk factors for osteoporosis, falls and fractures in hereditary myopathies and sporadic inclusion body myositis — A cross sectional survey

Molecular Genetics and Metabolism Reports, 2014
Background: The risk of osteoporosis is known in myopathies requiring long-term steroid treatment and Pompe disease, but not in other hereditary myopathies or sporadic inclusion body myositis (sIBM).
F. Danckworth, N. Karabul, A. Posa, F. Hanisch   +3 more
doaj   +1 more source

Serum-Circulating microRNAs in Sporadic Inclusion Body Myositis. [PDF]

Int J Mol Sci, 2023
Lucchini M, De Arcangelis V, Santoro M, Morosetti R, Broccolini A, Mirabella M.   +5 more
europepmc   +1 more source

Assessment of muscle damage using magnetic resonance imaging data in dermatomyositis and sporadic inclusion body myositis

Современная ревматология
Idiopathic inflammatory myopathies (IIM) are a group of rare autoimmune diseases characterized by muscle weakness. IIMs are characterized by heterogeneity of manifestations and include several variants, each of which has peculiarities related to ...
A. A. Kolomeychuk, L. P. Ananyeva, L. V. Ptichkina, A. N. Khelkovskaya-Sergeeva, D. O. Kazakov   +4 more
doaj   +1 more source

Activation of the γ-secretase complex and presence of γ-secretase-activating protein may contribute to Aβ42 production in sporadic inclusion-body myositis muscle fibers

Neurobiology of Disease, 2012
The muscle-fiber phenotype of sporadic inclusion-body myositis (s-IBM), the most common muscle disease associated with aging, shares several pathological abnormalities with Alzheimer disease (AD) brain, including accumulation of amyloid-β 42 (Aβ42) and ...
Anna Nogalska, Carla D'Agostino, W. King Engel, Valerie Askanas   +3 more
doaj   +1 more source

Th1 response and systemic treg deficiency in inclusion body myositis.

PLoS ONE, 2014
ObjectiveSporadic inclusion body myositis (sIBM), the most frequent myositis in elderly patients, is characterized by the presence muscle inflammation and degeneration.
Yves Allenbach, Wahiba Chaara, Michelle Rosenzwajg, Adrien Six, Nicolas Prevel, Federico Mingozzi, Julia Wanschitz, Lucile Musset, Jean-Luc Charuel, Bruno Eymard, Benoit Salomon, Charles Duyckaerts, Thierry Maisonobe, Odile Dubourg, Serge Herson, David Klatzmann, Olivier Benveniste   +16 more
doaj   +1 more source

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

Cells, 2019
Autophagy (self-eating) is a conserved cellular degradation process that plays important roles in maintaining homeostasis and preventing nutritional, metabolic, and infection-mediated stresses.
Rekha Khandia, Maryam Dadar, Ashok Munjal, Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Mohd. Iqbal Yatoo, Hafiz M.N. Iqbal, Karam Pal Singh, Sunil K. Joshi, Wanpen Chaicumpa   +10 more
doaj   +1 more source

Morphological and molecular comparison of HIV-associated and sporadic inclusion body myositis. [PDF]

J Neurol, 2023
Vogt S, Kleefeld F, Preusse C, Arendt G, Bieneck S, Brunn A, Deckert M, Englert B, Goebel HH, Masuhr A, Neuen-Jacob E, Kornblum C, Reimann J, Montagnese F, Schoser B, Stenzel W, Hahn K.   +16 more
europepmc   +1 more source