Advances in understanding grapevine downy mildew: From pathogen infection to disease management
Molecular Plant Pathology, Volume 25, Issue 1, January 2024.A review and discussion of recent understanding of Plasmopara viticola from multiple aspects, including infection cycle, disease symptoms, genome decoding, effector biology, and management and control strategies. Abstract Plasmopara viticola is geographically widespread in grapevine‐growing regions.
Junbo Peng +6 more
wiley +1 more source
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Fisher, LM +7 more
core +1 more source
Two-Metal Ion Mechanism of DNA Cleavage in CRISPR-Cas9 [PDF]
, 2019 CRISPR-Cas9 is a cutting-edge genome-editing technology, which employs the endonuclease Cas9 to cleave DNA sequences of interest. However, the catalytic mechanism of DNA cleavage and the critical role of the Mg2+ ions have remained elusive. Here, quantum–
Lorenzo, Casalino +2 more
core +1 more source
Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP [PDF]
, 2000 The 3' ends of most eukaryotic pre-mRNAs are generated by 3' endonucleolytic cleavage and subsequent polyadenylation. 3'-end formation can be influenced positively or negatively by various factors.
Gunderson, S. I. +4 more
core
Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]
, 2010 Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael +11 more
core +1 more source
, 2018 HBL-1 cells were lentivirally transduced with doxycycline-inducible expression vectors for MALT1, MALT1_1–781, MALT1_R781L, MALT1_C464A, MALT1B, MALT1B_1–770, or MALT1B_R770L. (A) Expression levels of endogenous and various transduced forms of MALT1 at 4
Yu-Hsuan Yang (5464682) +5 more
core +1 more source
Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
, 2005 Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz +12 more
core +1 more source
, 1991 When morphology and germination behaviour of sporangia produced by Phytophthora drechsleri were examined in the presence of 262 isolates of fungi and 64 isolates of actinomycetes in sterile, irradiated Eucalyptus bark compost (CEB), seventeen response ...
Sivasithamparam, K., Hardy, G.E.St.J.
core
The Cleavage Model, Ethnicity and Voter Alignment in Africa: Conceptual and Methodological Problems Revisited [PDF]
Recent research on political parties and ethnicity has challenged the conventional wisdom about ethnicity as the major factor that explains voter alignment in Africa.
Gero Erdmann
core
Towards Understanding Trans-Cleavage of Natural and Synthetic Nucleic Acids by Cas12a for Sensitive CRISPR Biosensing [PDF]
CRISPR/Cas systems have been widely utilized for the development of biosensing platforms for precision molecular diagnostics. Their remarkable biosensing performance critically depends on the efficiency of sequence-independent trans-cleavage in type V ...
Wei , Deng +5 more
core +2 more sources