Results 51 to 60 of about 8,457 (238)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Characteristics of the scientific researches in sport climbing (review of the articles, theses, programs, methodical works). [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011
The general estimation of the condition of the scientific developments will presented in sport climbing and on this base is specified the most perspective ways of scientific searching for in this area.
Sedliar Yu.V.
doaj  

Physiological demands and nutritional considerations for Olympic-style competitive rock climbing

Cogent Medicine, 2019
Rock climbing is a fast-growing sport. Nutritional recommendations for climbing performance remain limited. In a sport where reduced fuel availability/dehydration could result in declined performance and fatal error, nutrition is key to a successful ...
Marisa K. Michael, Oliver C. Witard, Lanae Joubert   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Executive Functions and Domain-Specific Cognitive Skills in Climbers

Brain Sciences, 2021
Athletes in a particular sport have specific cognitive skills acquired due to regular confrontation with sport-specific requirements. Studies show that the particular type of sport carried out and fostered by general physical activity impacts executive ...
Florian Heilmann
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hemodynamic and Cardiorespiratory Predictors of Sport Rock Climbing Performance [PDF]

Journal of Strength and Conditioning Research, 2018
AbstractFryer, SM, Giles, D, Garrido Palomino, I, de la O Puerta, A, and España-Romero, V. Hemodynamic and cardiorespiratory predictors of sport rock climbing performance.J Strength Cond Res32(12): 3543–3550, 2018—Rock climbing performance has been suggested to involve a notable contribution from aerobic metabolism.
Fryer, Simon M, Giles, David, Garrido, I, de la O Puerta, Alex, España-Romero, Vanesa   +4 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Determining the index of injuries requiring specialist treatment during boulder climbing on an artificial climbing wall

Journal of Education, Health and Sport, 2019
Introduction: Climbing was accepted as the official discipline at the Olympic Games in Tokyo in 2020. It is a sport that is becoming one of the most popular from extreme sports.
Grzegorz Zieliński, Estera Zięba, Michał Ginszt   +2 more
doaj   +3 more sources

Mental health in rock climbing

Current Issues in Sport Science
Introduction Rock climbing is an increasingly popular sport in the alpine region. It consists of different disciplines such as sport climbing, trad climbing or bouldering.
Christian Mikutta, Eva Allenbach, Christian Imboden   +2 more
doaj   +1 more source