Results 61 to 70 of about 729,689 (237)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
The physiological responses of sport climbing: a systematic review
, 2018 Background: With the increasing popularity of sport climbing, coupled with the recent inclusion of the sport in the 2020 Summer Olympics in Tokyo, a greater understanding of the physiological responses of sport climbing will aid in implementing training ...
Koh, Lynnette Siok Heng
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Czech terminological mountainneering and sport climbing dictionary [PDF]
, 2015 Title: Czech terminological mountaineering and sport climbing dictionnary. Goals: Create Czech terminological mountaineering a sport climbing dictionnary. Method: Searches primary and secondary literature. In the first case it was published dictionaries,
Jesenský, Ondřej
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Journal of Functional Morphology and Kinesiology, 2020 Sport-climbing popularity increased intensely over the past years. Particularly, children’s and adolescents’ interest therein is constantly growing. Despite a large effort in preventing injuries and muscle overloads, a fine-tuned training for
Ludovica Gasbarro +6 more
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Performance diagnostics in sport climbing - test manual [PDF]
, 2020 In this manual a climbing specific test battery is described which was developed at the Augsburg University.
Winkler, Marvin +2 more
core
Podium, 2021 Strength endurance is the physical capacity to maintain strength at a constant level for the duration of a given sporting gesture, a determining capacity in many sports, where sport climbing is no exception; therefore, the theoretical-practical study ...
Luis Fernando Cañadas Gómez de La Torre
doaj