Results 81 to 90 of about 729,689 (237)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

What drives people up the wall? The case of indoor climbing (sport climbing) in New Zealand

, 2003
What drives people up the wall?
S Leberman (13755871), Cadeyrn Gaskin (13063494)   +1 more
core  

Physiology of sport climbing [PDF]

, 2009
El presente trabajo revisa la literatura científica existente sobre la escalada deportiva con el objetivo de analizar en profundidad las características antropométricas y fisiológicas del escalador deportivo, así como las exigencias fisiológicas en el ...
Jiménez Pavón, David, Castillo Garzón, Manuel J., Gutiérrez, Ángel, Ruiz Ruiz, Jonatan, Artero, Enrique G., España Romero, Vanesa, Ortega Porcel, Francisco Bartolomé   +6 more
core   +1 more source

Profil of Sumedang Sport Climbing Athlete

Active: journal of physical education, sport, health and recreation
There are many sport climbing athletes in Sumedang. However, the level of motivation to achieve is still low, as seen from the achievements and intensity of the training they do.
A. R. Feliansyah Wiguna, Indra Safari, Rizal Ahmad Fauzi   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Sport Climbing : Foundations and Training Essentials

Preface: Sport climbing is more than just a physical challenge; it is a dynamic blend of strength, technique, problem-solving, and mental resilience. As both a competitive climber and a researcher, I have experienced the demands and rewards of this sport.
Gilić Škugor, Barbara
core   +1 more source

Vertical locomotion improves horizontal locomotion: effects of climbing on gait and other mobility aspects in Parkinson’s disease. A secondary analysis from a randomized controlled trial

Journal of NeuroEngineering and Rehabilitation
Background In the Climb Up! Head Up! trial, we showed that sport climbing reduces bradykinesia, tremor, and rigidity in mildly to moderately affected participants with Parkinson’s disease.
Agnes Langer, Clint Hansen, Dominik Roth, Agnes Santer, Anna Flotz, Jakob Gruber, Laurenz Wizany, Sebastian Hasenauer, Rochus Pokan, Peter Dabnichki, Marco Treven, Sarah Zimmel, Michaela Schmoeger, Ulrike Willinger, Lucia Gassner, Christof Brücke, Walter Maetzler, Heidemarie Zach   +17 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source