Results 51 to 60 of about 386,068 (293)

2018 International Consensus Statement on Golf and Health to guide action by people, policymakers and the golf industry [PDF]

, 2018
Scientific and public interest relating to golf and health has increased recently. Players, potential players, the golf industry and facilities, and decision makers will benefit from a better understanding of how to realise potential health benefits and ...
Archibald, Daryll, Barker, Kevin, Foster, Charlie, Grant, Liz, Hawkes, Roger A., Kelly, Paul, Murray, Andrew D., Murray, Iain Robert, Mutrie, Nanette   +8 more
core   +5 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Southern California marine sport fishing from privately-owned boats: catch and effort for July-September 1981 [PDF]

, 1982
The catch landed and effort expended by private-boat sport fishermen were studied in southern California between July and September 1981, in order to determine the impact of one segment of the sport fishery on local marine resources.
Racine, Denyse
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

State of Play in Western New York: Analysis and Recommendations [PDF]

, 2017
This report offers an independent assessment of the state of play for kids and sports in the eight-county region comprising Western New York-Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Niagara, Orleans, and Wyoming counties.
Aspen Institute Sports & Society Program, Community Foundation of Greater Buffalo, Ralph C. Wilson, Jr. Foundation   +2 more
core   +1 more source

Olympic legacy and cultural tourism: Exploring the facets of Athens' Olympic heritage [PDF]

, 2013
This study examines the effects of the Olympic Games on Athens’ cultural tourism and the city’s potential to leverage the Olympic legacy in synergy with its rich heritage in order to enhance its tourism product during the post-Games period.
Alexiou C., Ashworth G.J., Asprogerakas E., Boniface B.G., Brown G., Burbank M.J., Chalip L., Creswell J.W., Denzin N.K., Derrett R., Gammon S., Georgios Boustras, Gold J.R., Gold M.M., Gold M.M., Irish Tourist Board, Kalogeropoulou H., Kitroeff A., Kostof S., Koutoulas D., MacAloon J.J., Mangan J.A., Miles M., Milionis S., Nikolaos Boukas, Papageorgiou-Venetas A., Ritchie J.R.B., Roche M., Sykianaki C., Traganou J., Travlou P., Tyler N., Vassilios Ziakas, Weed M., Yin R.K., Zentelis P., Zografos G.   +36 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Informal sport spaces as beacons of social cohesion: a case study of informal sport in “Chicago,” Western Cape, South Africa

Frontiers in Human Dynamics
This paper presents research conducted in an informal settlement in Paarl, Western Cape (South Africa). The research demonstrates the importance of team sport activities as an instrument to encourage community cohesion.
Anele Horn, Willis Marais
doaj   +1 more source