Results 71 to 80 of about 25,279 (262)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

THE CURRENT STATE OF PREPAREDNESS OF THE ROSPOTREBNADZOR INSTITUTIONS FOR PROVISION OF THE RADIATION SAFETY FOR THE 2018 WORLD FOOTBALL CHAMPIONSHIP

open access: yesРадиационная гигиена, 2018
This study is focused on the main activities on provision of the radiation safety as a part of sanitary surveillance and radiation terrorism counteraction during the 2018 World Football Championship.
K. A. Saprykin
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Evaluation indice for risking level lowering of the physical Recreational Facilities, Accsesories and Implements

open access: yesPodium, 2013
The present work has the general objective to elaborate evaluation indices for risking level lowering of the physical recreational facilities, tools and implements in the different educational and sport institutions of the territory.
Jesús I. Benítez-Llanes   +2 more
doaj  

Physical culture and sport as factors of socializations to personality [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2010
The analysis of publications is resulted on the topic of research. Essence of physical culture and sport is exposed and its place is certain in the system of public relations. The socializing function of sport is considered.
Mamaeva E.V., Mamaev D.Y.
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

MENADŽMENT RIZIKA I BEZBEDNOSTI SPORTSKOG DOGAĐAJA [PDF]

open access: yesSport Mont, 2011
The acquired information and knowledge that the public in the sport events: from heterogeneous sport audience, media and sport superstructure to sports organizations relate to the security in a passive way, in an expectation that the risk of security ...
Srećko Novaković
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

CREATING A MODEL OF MANAGEMENT IN THE SECURITY SYSTEM OF SPORTS EVENTS [PDF]

open access: yesSport Mont, 2012
The acquired information and knowledge that the public in the sport events: from heterogeneous sport audience, media and sport superstructure to sports organizations relate to the security in a passive way, in an expectation that the risk of security ...
Dragan Đuranović   +2 more
doaj  

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