Results 121 to 130 of about 306,568 (267)

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

Mammary-tumour incidence in Sprague-Dawley rats treated with 7,12-dimethylbenz(a)anthracene: Effect of pregnancy and lack of effect of unilateral lactation

, 1981
Brian P. Moore, Thomas J. Hayden, I. A. Forsyth   +2 more
openalex   +1 more source

RAT: Adversarial Attacks on Deep Reinforcement Agents for Targeted Behaviors [PDF]

arXiv
Evaluating deep reinforcement learning (DRL) agents against targeted behavior attacks is critical for assessing their robustness. These attacks aim to manipulate the victim into specific behaviors that align with the attacker's objectives, often bypassing traditional reward-based defenses.
arxiv  

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Systemic candidiasis in Sprague-Dawley rats [PDF]

, 1996
Axel Schmidt
openalex   +1 more source

Cytogenetic, Hematobiochemical, and Histopathological Assessment of Albino Rats (Rattus norvegicus) Fed on Gluten Extracts [PDF]

arXiv
Background: Literature shows that most of the information on the toxicity of gluten is generated from survey and observational studies, resulting in inconsistent outcomes and a decrease in the acceptability of gluten-rich foods. To determine gluten's safety, an in-depth in vitro and in vivo toxicological examination is required. This enables scientists
arxiv  

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Assessment of maternal toxicity, embryotoxicity and teratogenic potential of sodium chlorite in Sprague-Dawley rats.

, 1982
Daniel Couri, Cary Miller, Richard J. Bull, John M. Delphia, E M Ammar   +4 more
openalex   +1 more source

Accelerating Sono‐Piezoelectric Charge Transport for Antibacterial Therapy and Bone Regeneration by Metal‐Deficient TiO2 Spin‐Polarization Effect

Advanced Science, EarlyView.
The deficient TiO2 (DTO) and Barium titanate (BTO) heterojunction treats osteomyelitis through SDT. The spin‐polarization effect induced by the unpaired spin electrons in Ti atoms can expedite the transfer of ultrasonic piezoelectric charges in BTO, enhancing surface sonocatalytic efficiency.
Chaofeng Wang, Shuilin Wu, Congyang Mao, Liguo Jin, Hanpeng Liu, Yufeng Zheng, Chunyong Liang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Xiangmei Liu   +10 more
wiley   +1 more source