Results 241 to 250 of about 330,960 (360)

Subchronic Toxicities of Four Per- and Polyfluoroalkyl Substances (PFASs) by Oral Exposure in Sprague-Dawley Rats. [PDF]

Toxics
Kenyon EM, Devito MJ, Patlewicz G, Adams LD, Thomas RS, Ambroso JL, Yang X, Blake JC, Upadhyay BG, Furr J, Hughes MF.   +10 more
europepmc   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Ameliorative effects of Berberine chloride against 5-fluorouracil-induced cardiotoxicity in Sprague Dawley rats. [PDF]

Sci Rep
Labib MA, Saeed OS, ElSharkawy SH, Khattab MS, El-Zorba HY, Abo-El-Sooud K.   +5 more
europepmc   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

Acute and Subchronic Exposure to Hemp (<i>Cannabis sativa</i> L.) Leaf Oil: Impacts on Vital Organs in Sprague-Dawley Rats. [PDF]

Pharmaceuticals (Basel)
Maneesai P, Duangjinda M, Labjit C, Khamseekaew J, Potue P, Poasakate A, Pakdeechote P.   +6 more
europepmc   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Safety Evaluation of Contezolid (MRX-I) Versus Linezolid in Sprague-Dawley Rats. [PDF]

Drugs R D
Wei L, Hong M, Lu M, Qian Y, Li Q, Tang N, Li H, Chang Y, Qiu Y.   +8 more
europepmc   +1 more source

Essential oil from Korean Chamaecyparis obtusa leaf ameliorates respiratory activity in Sprague‑Dawley rats and exhibits protection from NF-κB-induced inflammation in WI38 fibroblast cells

, 2018
Suchismita Raha, Seong Min Kim, Ho Lee, Sang Kook Lee, Jeongyun Heo, Venu Venkatarame Gowda Saralamma, Sang Keun Ha, Eun Sun Kim, Sung Phil Mun, Gon Sup Kim   +9 more
openalex   +2 more sources

Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

Advanced Science, EarlyView.
This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie, Jieting Li, Junjie Cai, Siyu Zhang, Yingling Miao, Ning Hou, Gen He, Maobin Xie, Xiyong Yu, Mingen Xu, Guosheng Tang   +13 more
wiley   +1 more source

Therapeutic effect of <i>Lepidium peruvianum Chacon</i> mediated silver nanoparticles on fertility in adult male Sprague-Dawley rats. [PDF]

RSC Adv
Hamza A, Taj MB, Alsabban MM, Altowerqi AM, Jahan S, Afzal A, Alghamdi S.   +6 more
europepmc   +1 more source