Results 221 to 230 of about 207,934 (261)

Respiration in Sprague-Dawley Rats During Pregnancy

Inhalation Toxicology, 2006
Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
Teresa L, Leavens, Carl U, Parkinson, R Arden, James, Dennis, House, Barbara, Elswick, David C, Dorman   +5 more
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Urinary chemistry of the normal Sprague-Dawley rat

Urological Research, 1993
On the basis of metabolic in vivo studies using the adult male Sprague-Dawley rat, we present a comprehensive summary of urine species measurements conducted in our laboratory over the last several years, as well as those present in the literature.
P N, Shevock, S R, Khan, R L, Hackett
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Spontaneous leukaemia in a sprague-dawley rat

Experientia, 1962
Description d'un cas de chloroleucemie myeloide chez un rat de souche Sprague-Dawley, presentant quelques modifications peu communes des tubes renaux.
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Carcinogenicity of 8-nitroquinoline in Sprague—Dawley rats

Cancer Letters, 1978
8-Nitroquinoline was added to the semisynthetic diet of outbred Sprague-Dawley rats for 48 weeks. Squamous cell carcinomas of the upper digestive tract (tongue and esophagus), but especially of the forestomach, occurred among the higher concentration groups.
M, Takahashi, T, Shirai, S, Fukushima, K, Hosoda, S, Yoshida, N, Ito   +5 more
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Spontaneous neoplasms in aged sprague-dawley rats

Archives of Toxicology, 1992
Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid ...
M, Chandra, M G, Riley, D E, Johnson
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Developmental Toxicity of Thiodiglycol in Sprague-Dawley Rats

International Journal of Toxicology, 2007
Thiodiglycol (TG), a hydrolysis product of sulfur mustard (HD), is a potential contaminant of soil and water at certain military sites. To establish developmental toxicity criteria for TG, an oral developmental toxicity study was conducted in Sprague-Dawley rats.
John T, Houpt, Lee C B, Crouse, Richard A, Angerhofer, Glenn J, Leach, Gunda, Reddy   +4 more
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Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in sprague-dawley rats

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1977
Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals
W, Lijinsky, H W, Taylor
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The nephrotoxic potential of styrene in sprague-dawley rats

Toxicology Letters, 1983
Pre-fasted (16 h) Sprague-Dawley male rats were treated i.p. with 0, 0.2, 0.4, 0.8 and 1.2 g/kg of styrene in corn oil. Renal functions were assessed at 0-24, 24-48 and 48-72 h after the exposure. Urinary creatinine was decreased at 0.8 g/kg of styrene during 0-24 h after the treatment compared to control, whereas such a decrease was noticed in 1.2 g ...
S, Chakrabarti, J, Brodeur
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Olanzapine Induced Thrombocythemia in Sprague‐Dawley Rats

Drug and Chemical Toxicology, 2004
Olanzapine was administered orally (20 mg/kg/day) in Sprague-Dawley rats. Forty-eight male Sprague-Dawley rats were divided into eight groups of six animals each. Four groups of animals received olanzapine for 7, 14, 21 and 48 days. There were no significant changes in hematological, clinical biochemistry parameters and superoxide dismutase activity in
Manoj, Patel, Cherian, Bapu, Harish, Padh, Manish, Nivsarkar   +3 more
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Spontaneous brain tumours in Sprague-Dawley rats

Food and Chemical Toxicology, 1986
Data were collected over a 5-yr period on brain tumours occurring spontaneously among Sprague-Dawley-derived rats in the HRC laboratories. Gliomas, like meningiomas, tended to occur more among males than in females, and in general appeared to be lesions of older rats. Astrocytic tumours of rats were less differentiated than those in man.
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