Results 131 to 140 of about 246,656 (307)

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Compared lung geometry between Wistar, Long-Evans, and Sprague-Dawley rats.

, 2019
Compared lung geometry between Wistar, Long-Evans, and Sprague-Dawley rats.
Bruno Louis (4248580), James B. Grotberg (2315173), Daniel Isabey (4248577), Marcel Filoche (4248574), Joshua Satalin (5545628), Alireza Kazemi (2818927), Louis A. Gatto (5545616), Sarah Baker (813920), Gary F. Nieman (5545625)   +8 more
core   +1 more source

Absent or Not?: Classically Conditioning Spike-and-Wave Discharge in Sprague Dawley Rats

, 2016
Spike-and-wave discharge is an electroencephalographic brainwave found in many rodent species and studied rigorously in inbred laboratory rats (WAG/Rij and GAERS strains) for its similarities to absence epilepsy.
Taylor, Jeremy
core   +1 more source

Methanolic leaf extract of Pericopsis laxiflora (benth. ex baker) meeuwen protects against cadmium-induced testicotoxicity in male sprague-dawley rats via antioxidant capabilities

Fountain Journal of Natural and Applied Sciences (FUJNAS)
Pericopsis laxiflora (Benth) Meeuwen is used in African folk medicine to mitigate numerous infections. This study evaluated the antioxidant, phytochemical and antimicrobial activities and protective potential of P.
Abdulrasaq Oyedeji, Christian Ukonu, Semiu Lawal, Luqmon Azeez   +3 more
doaj   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

The pharmacokinetic parameters of WB403 in Sprague-Dawley rats.

, 2015
The oral bioavailability (F%) was calculated as F (%) = AUC0-∞(p.o.) / AUC0-∞(i.v.) × Dose (i.v.) / Dose (p.o.). Values are mean ± SEM (n = 5).The pharmacokinetic parameters of WB403 in Sprague-Dawley rats.
Panpan You (775313), Huaqing Chen (198618), Chunbing Zheng (775311), Tongtong Wang (775312), Yiqing Yang (775314), Yongliang Zhao (400757), Xin Wang (91924), Wenbo Zhou (102293), Yihua Chen (107400), Mingyao Liu (38997), Jian Luo (133137)   +10 more
core   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Spatial abilities in adolescent-stressed and unstressed male Sprague-Dawley rats.

, 2015
*Indicates significant at p < 0.05.Spatial abilities in adolescent-stressed and unstressed male Sprague-Dawley rats.
Michael J. Sheriff (827991), Lauren E. Chaby (827990), Victoria A. Braithwaite (827994), Amy M. Hirrlinger (827992), Thomas B. Fetherston (827993), James Lim (605968)   +5 more
core   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source