Results 181 to 190 of about 317,880 (361)

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

open access: yesAdvanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang   +6 more
wiley   +1 more source

Spontaneous Skin Neoplasms in Aged Sprague-Dawley Rats [PDF]

open access: bronze, 1992
Gary M. Zwicker   +3 more
openalex   +1 more source

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

open access: yesAdvanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong   +3 more
wiley   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

open access: yesAdvanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu   +18 more
wiley   +1 more source

ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS

open access: yesPakistan Armed Forces Medical Journal, 2019
Objective: To investigate the genotoxic effect of cigarette smoking in Sprague Dawley rats. Study Design: Randomized experimental study. Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan 2013 to Jul 2013.
Aneela Jamil   +2 more
doaj  

Nim on Integer Partitions and Hyperrectangles [PDF]

open access: yesarXiv
We describe PNim and RNim, two variants of Nim in which piles of tokens are replaced with integer partitions or hyperrectangles. In PNim, the players choose one of the integer partitions and remove a positive number of rows or a positive number of columns from the Young diagram of that partition.
arxiv  

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

open access: yesAdvanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi   +12 more
wiley   +1 more source

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