Results 41 to 50 of about 317,880 (361)

The hypotensive effect of activated apelin receptor is correlated with \b{eta}-arrestin recruitment [PDF]

Elie Besserer-Offroy, et al. Pharmacol Res, Epub 9 March 2018, 2018
The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease.
arxiv   +1 more source

Cutaneous Hybrid Cyst in a Sprague-Dawley Rat

Journal of Toxicologic Pathology, 2012
This report describes a spontaneous hybrid cyst in a Sprague-Dawley (SD) rat. A 52-week-old, male SD rat had a cutaneous cyst on the left mystacial pad. Histologically, the cyst wall showed infundibular differentiation with keratohyalin granules in the granular layer and matrical differentiation comprising basaloid epithelial cells with trichohyalin ...
Mariko Shirota, Kinji Shirota, Haruka Sakashita, Yosuke Sakurada, Junichi Kamiie, Saori Araki, Ryosuke Kobayashi, Kyohei Yasuno   +7 more
openaire   +4 more sources

Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats [PDF]

, 2018
Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus.
Cacao, Eliedonna, Cucinotta, Francis A., Kapukotuwa, Sidath   +2 more
core   +3 more sources

Antihyperlipidemic effect of Berberis orthobotrys in hyperlipidemic animal models

Bangladesh Journal of Pharmacology, 2014
The present study was undertaken to evaluate antihyperlipidemic effect of aqueous methanolic extract of Berberis orthobotrys in experimentally induced hyperlipidemic animal models. Atorvastatin was used as standard drug.
. Alamgeer, Aqsa Ghuffar, Taseer Ahmad, Muhammad Naveed Mushtaq   +3 more
doaj   +1 more source

Spontaneous Complex Odontoma in a Sprague-Dawley Rat.

Journal of Veterinary Medical Science, 2002
Complex odontoma from a female Sprague-Dawley rat is described histopathologically. Necropsy revealed a hard (bony), white mass (3.0 x 3.0 x 2.1 cm) on the left mandible. Microscopically, the mass consisted of islands or nests of epithelial and mesenchymal elements that formed abortive tooth structures.
Jung-Hyun Kim, Jin Seok Kang, Byeongwoo Ahn, Seung Kwon Ha, Dae Joong Kim, Dong Un Han, Dong Deuk Jang, Kwonil Jung, Han Kook Chung, Chanhee Chae, Chuel Kyu Kim, Changsun Choi, Ki Taek Nam, Wan-Seob Cho   +13 more
openaire   +5 more sources

Effects of cocaethylene on dopamine and serotonin synthesis in Long–Evans and Sprague–Dawley brains [PDF]

, 1998
We examined the behavioral and neurochemical effects of cocaethylene treatment in Long–Evans ( LE). and Sprague–Dawley (SD) rats. Cocaethylene-induced behaviors were significantly less in LE rats.
Baumann, Dr. M.H., Horowitz, Dr. J.M., Kristal, Dr. M.B., Torres, Dr. G.   +3 more
core   +1 more source

Characterization of Diabetic Neuropathy in the Zucker Diabetic Sprague-Dawley Rat: A New Animal Model for Type 2 Diabetes

Journal of Diabetes Research, 2014
Recently a new rat model for type 2 diabetes the Zucker diabetic Sprague-Dawley (ZDSD/Pco) was created. In this study we sought to characterize the development of diabetic neuropathy in ZDSD rats using age-matched Sprague-Dawley rats as a control.
Eric P. Davidson, Lawrence J. Coppey, Amey Holmes, Sergey Lupachyk, Brian L. Dake, Christine L. Oltman, Richard G. Peterson, Mark A. Yorek   +7 more
doaj   +1 more source

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Abraham, Abs, Akin, Aronica, Aronica, Ashraf, Auvin, Bar-Klein, Basler, Bhala, Bozzi, Cacheaux, Cerri, Citraro, Dianzani, Diaz-Hernandez, Dityatev, Drion, Engel, Fabene, Friedman, Fu, Fukasawa, Galanopoulou, Ganesh, Gorter, Groettrup, Groettrup, He, Heinemann, Henshall, Holtman, Huang, Iori, Iyer, Jiang, Jimenez-Pacheco, Jimenez-Pacheco, Jung, Kim, Kim, Kwon, Liang, Liepe, Louboutin, Louboutin, Marchi, Maroso, Maroso, Marusich, McRae, Mishto, Mishto, Mishto, Mishto, Mishto, Noe, Nomura, O'Neill, Podojil, Polascheck, Pollock, Prabowo, Quan, Ravizza, Ravizza, Rojas, Rojas, Rojas, Rojas, Roseti, Roseti, Ruden, Sadowski, Scheppingen, Scheppingen, Serrano, Takenouchi, Thalhammer, Varvel, Vezzani, Vezzani, Vezzani, Vezzani, Vezzani, Vliet, Vliet, Volonte, Vries, Wei, Zanker, Zeng, Zhang   +92 more
core   +4 more sources

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Determination of Biological Activity of Gonadotrophins in Randombred and Sprague Dawley Rats. Part 2. Determination of Biological Activity of Luteinising Hormone

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The tendency towards reducing the use of laboratory animals in pharmaceutical quality assessment, along with the development of new technologies for gonadotrophin production, necessitate the development of novel assays to determine the ...
T. A. Batuashvili, E. O. Chechetova, P. V. Shadrin, N. P. Neugodova   +3 more
doaj   +1 more source