Results 51 to 60 of about 246,656 (307)

Determination of Biological Activity of Gonadotrophins in Randombred and Sprague Dawley Rats. Part 2. Determination of Biological Activity of Luteinising Hormone

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The tendency towards reducing the use of laboratory animals in pharmaceutical quality assessment, along with the development of new technologies for gonadotrophin production, necessitate the development of novel assays to determine the ...
T. A. Batuashvili, E. O. Chechetova, P. V. Shadrin, N. P. Neugodova   +3 more
doaj   +1 more source

Engineering Pendant Group Chemistry to Control Hydrophilicity and Oxidative Degradation of Thioketal‐Based Biomaterials

Advanced Functional Materials, EarlyView.
Thioketal (TK) polymers are promising biomaterials due to their selective biodegradation by reactive oxygen species (ROS), but they respond slowly to physiologic doses of ROS. Here, the TK bond's pendant groups are modified to enhance the degradation of TK‐based implants both in vitro and in vivo.
Karina A. Bruce, Dylan W. Marques, Alan J. Fullenkamp, Emma‐Louise Lowell, Rais B. Fataki, Jake D. Ryan, John R. Martin   +6 more
wiley   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Uninephrectomy in rats on a fixed food intake potentiates both anorexia and circulating cytokine subsets in response to LPS.

Frontiers in Immunology, 2015
Recent human studies have suggested that mild reduction in kidney function can alter immune response and increase susceptibility to infection. The role of mild reduction in kidney function in altering susceptibility to bacterial lipopolysaccharide (LPS ...
Denis eArsenijevic, Denis eArsenijevic, Jean-Pierre eMontani, Jean-Pierre eMontani   +3 more
doaj   +1 more source

Spontaneous Nephroblastoma in 3 Sprague-Dawley Rats

The Japanese Journal of Veterinary Science, 1982
SD系ラット3例に自然発生した腎臓腫瘍の病理組織学的検索を行った. 腫瘍は管を形成する一層の上皮性細胞と, その周囲に塊状に増殖する未分化な芽種性細胞から成り, 主に膠原線維から成る間質で分画されていた. この組織構築から腫瘍は腎芽腫と判断された. また, これらの上皮性細胞と芽種性細胞には電顕的に本質的な差を認めず, 組織構築が後腎胚種質に類似することと合わせ, 本腫瘍は腎実質上皮性の腫瘍であると考えられた.
INUI, Toshihide, TAKADA, Hiroshi, OKANIWA, Azusa, FUJINAMI, Fujio, DOI, Kunio   +4 more
openaire   +3 more sources

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Spontaneous Iron Overload in Sprague-Dawley Rats [PDF]

Toxicologic Pathology, 1997
In a review of the toxicological studies performed in our laboratory during the period 1986-1995, we occasionally observed significant iron overloading in the liver. Liver tissue was examined by light and electron microscopy, and the results were analyzed by sex and age (7, 9, 11, 19, 31, 59, and 111 wk).
R, Masson, N O, Roome
openaire   +2 more sources

Hydrogel Microtube Drug Carrier for Catheter‐Based Intravascular Therapy

Advanced Healthcare Materials, EarlyView.
This paper proposes hydrogel microtube carriers composed of barium alginate gel, enabling long‐term vascular retention without interrupting blood flow. Intravascular treatments have long been attracting attention for therapeutic efficacy, yet practical delivery methods remained unestablished.
Shota Sato, Hiroki Ohta, Naoki Takakura, Kentaro Kasa, Teppei Komatsu, Dai Kejia, Misato Yoshioka, Hirotaka James Okano, Hiroaki Onoe   +8 more
wiley   +1 more source

Photoreceptors in Sprague-Dawley rats.

, 2013
Plastic-embedded sections of retinas from wild-type Sprague-Dawley rats of PD 8 (A), 12 (B), 16 (C), 20 (D), 30 (E), and 60 (F) were examined by light microscopy (superior regions). The ONL is indicated in each panel by a white vertical bar.
Yiwen Li (354034), Lingyu Luo (354037), Alan M. Laties (110017), Matthew M. LaVail (178375), Deqiang Huang (354035), Paul Stabila (366649), Konrad Kauper (366647), Weng Tao (366644), Rong Wen (181335)   +8 more
core   +1 more source