Results 51 to 60 of about 908,208 (245)

The effect of 12 weeks of intermittent aerobic exercise on endothelin-1 concentration of plasma in adult rats

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
Introduction: Endothelin is a vasoconstrictor which is released from the endothelium. The aim of the present study was to investigate the effect of intermittent aerobic exercise on the endothelin-1 concentration of plasma as an important indicator of ...
A Qassemian, M Koushki Jahromi
doaj   +2 more sources

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Beacon-like immunoreactivity in the hypothalamus of Sprague–Dawley rats

, 2002
Distribution of the novel peptide beacon in the hypothalamus of Sprague-Dawley rats was examined by immunohistochemical methods. Beacon-immunoreactive (irBC) neurons were found in the paraventricular, supraoptic, and accessory neurosecretory nuclei, and ...
Brailoiu, G. Cristina, Dun, Nae J., Siok L. Dun, Dun, Siok L., Nae J. Dun, Chang, Jaw Kang, Yang, Jun, G.Cristina Brailoiu, Sonya Castellino, Castellino, Sonya, Jaw Kang Chang, Jun Yang   +11 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Agonistic Postures Elicited by Subdermal Shock in Sprague-Dawley and Long-Evans Rats

, 1975
Different agonistic postures were elicited by subdermal shock in Long-Evans and Sprague-Dawley rats. 0-, 1-, 2-, and 3-mA shocks were used. All postures were reliably identified by independent observers at greater than chance levels, although absolute ...
D. A. Powell, Sidney D. Duncan
core   +1 more source

Social play behavior, ultrasonic vocalizations and their modulation by morphine and amphetamine in Wistar and Sprague-Dawley rats [PDF]

, 2013
Rationale Social play behavior is the most characteristic social behavior in young mammals. It is highly rewarding and crucial for proper neurobehavioral development.
PALMERY, Maura, prof.dr. Cuomo, V., CAMPOLONGO, Patrizia, Manduca, A., Vanderschuren, L.J.M.J., L.J. Vanderschuren, TREZZA, Viviana, Pamery, M., Campolongo, P., Trezza, V., A. Manduca, CUOMO, VINCENZO   +11 more
core   +2 more sources

Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer

Acta Veterinaria, 2014
The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats.
Emília Hijová, Viktoria Szabadosova, Jana Štofilová, Rastislav Salaj, Alojz Bomba   +4 more
doaj   +1 more source

STUDY OF TOXICITY OF SAKHABACTISUBTIL IN RATS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2017
Aim. Determine safety and potential toxic effects of Sakhabactisubtil during its multifold intra-gastric administration to CD rats. Materials and methods.
M. P. Neustroev, A. N. Murashev, D. A. Bondarenko, A. M. Stepanova, N. P. Tarabukina   +4 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source