Results 71 to 80 of about 908,208 (245)

Daidzein ameliorates peripheral neuropathy in Sprague Dawley rats

Frontiers in Pharmacology
Neuropathy is the most common disorder comprising peripheral nerve damage in diabetic patients. Prolonged hyperglycaemia and oxidative stress cause metabolic imbalance and are the key reasons for the development of diabetic neuropathy.
Ankit P. Laddha, Yogesh A. Kulkarni
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Prevalence of hand-induced 22-kHz ultrasonic vocalizations in Sprague-Dawley and Wistar Han rats.

, 2022
Prevalence of hand-induced 22-kHz ultrasonic vocalizations in Sprague-Dawley and Wistar Han rats.
Kimberly Navetta (14141964), Chang-Ning Liu (6260843), Seo-Kyoung Hwang (10431836), Cheryl Tyszkiewicz (11352473), Melissa Dragon (14141961), Rebecca Ferreira (3490868)   +5 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Hematology, clinical biochemistry, and serum IgE and histamine levels in male Sprague-Dawley (SD) rats.

, 2021
Hematology, clinical biochemistry, and serum IgE and histamine levels in male Sprague-Dawley (SD) rats.
Jangmi Lee (1875595), Seongsung Kwak (11349328), Chang-Hoon Rhee (11349331), Junhyung Kim (1277919), Woo-Chan Son (295963), Won-ho Kang (11349334), Mi-Sun Park (597691), Gi-Hyeok Yang (1310064)   +7 more
core   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Hematology, clinical biochemistry, and serum IgE and histamine levels in female Sprague-Dawley (SD) rats.

, 2021
Hematology, clinical biochemistry, and serum IgE and histamine levels in female Sprague-Dawley (SD) rats.
Jangmi Lee (1875595), Seongsung Kwak (11349328), Chang-Hoon Rhee (11349331), Junhyung Kim (1277919), Woo-Chan Son (295963), Won-ho Kang (11349334), Mi-Sun Park (597691), Gi-Hyeok Yang (1310064)   +7 more
core   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Blood biochemical analysis and published reference values for biochemical analytes in male Sprague-Dawley rats.

, 2021
Blood biochemical analysis and published reference values for biochemical analytes in male Sprague-Dawley rats.
Nuria Garcia-Carrillo (6729860), Lidia Oltra (6729857), Victor Lopez-Lopez (11851309), Ricardo Robles-Campos (11182965), Carlos Alberto González-Bermúdez (11851315), Guillermo Carbonell (6729851), Roberto Brusadin (11851318), Diego de Gea (11851312), Asunción Lopez-Conesa (11851321)   +8 more
core   +1 more source

Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats

Journal of Rawalpindi Medical College, 2017
Background: To evaluate the effects of type 2 diabetes mellitus on fatigability of soleus (slow) and extensor digitorium longus (EDL) (fast) muscles of female Sprague Dawley rats.
Mehvish Ashfaq
doaj