Results 41 to 50 of about 357,915 (368)

Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach [PDF]

, 2019
Open access articleThe aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation.
Keppler, Julia K, Owen, Martin, Schlindwein, W. S., Schwarz, Karin, Theismann, Eva-Maria   +4 more
core   +2 more sources

Analysis of Spray Flow Pattern and Spray Combustion Characteristics.

Journal of the Fuel Society of Japan, 1991
The analysis of spray flow was very important for the spray combus-tion simulation. In this study, the models for the spray pattern and the motion of spray dro-plets in the gas flow were investigated to improve the simulation accuracy. The spray pat-tern was expressed by the random sampling of spray angles from a normal probability de-nsity ...
Tomohiko FURUHATA, Hideyuki AOKI, Shoji TANNO, Takatoshi MIURA   +3 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Numerical Analysis of Liquid Hydrogen Atomization in a Premixing Tube Using a Volume of Fluid-to-Discrete Particle Model Approach

Aerospace
This paper examines the atomization characteristics of liquid hydrogen fuel in a premixing tube under different operating conditions. Hydrogen fuel’s unique injection morphology and atomization behavior were analyzed using the Volume of Fluid-to-Discrete
Abdalazeem Adam, Weifeng He, Dong Han, Yuxin Fan, Omer Musa   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Design of high-dispersion atomization nozzle for direct injection Diesel engine (Effects of shapes and measurement of nozzle holes of injection nozzle on spray and flow characteristics)

Nihon Kikai Gakkai ronbunshu, 2015
It is demanded to obtain excellent spray characteristics that is able to obtain excellent combustion characteristics in order to reduce noxious exhaust gas, especially, carbon dioxide, nitrogen oxide and particulate matter.
Nobushige TAMAKI, Kazuma NISHIKAWA
doaj   +1 more source

Numerical prediction of the spray from an air-assisted fuel injection system via Eulerian–Lagrangian approach

Energy Reports, 2021
Air-assisted fuel injection (AAFI) systems may be installed in aviation piston engines for atomization of heavy fuels. However, there are few studies on the in-cylinder air-assisted spray characteristics, which affects the improvement of AAFI engine ...
Bingxuan Du, Zhenfeng Zhao
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Visualization study on spray and ignition characteristics of high proportion methanol / PODE blended fuel

Journal of Thermal Science and Technology
With the increasingly stringent emission requirements for shipping, methanol is a promising alternative fuel. The effects of mixing ratio and ambient temperature on the spray and ignition characteristics of high proportion methanol / Polyoxymethylene ...
Rongkang SUN, Lijiang WEI, Wei SONG, Xiuwei LU, Chen HUANG   +4 more
doaj   +1 more source

Improvement of spray characteristics of injection nozzle for direct injection Diesel engine

Nihon Kikai Gakkai ronbunshu, 2017
It is important to improve spray characteristics of an energy conversion engine in order to reduce carbon dioxide and exhaust gas emission. The purpose of this study is to design and develop high-dispersion injection nozzle for direct injection Diesel ...
Nobushige TAMAKI, Takuya MUROTANI, Takato HARADA   +2 more
doaj   +1 more source