Results 91 to 100 of about 185,380 (253)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Alice Springs Town Council strategic plan 2004-2009

, 2004
Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)

core  

An eco-theological interpretation of Proverbs 5:15-20 in the light of water crises experienced in present-day Africa

Old Testament Essays, 2017
Proverbs 5:15-20 is not about ecological issues such as water management. However, the biblical author employed water-related metaphors as a way of speaking about faithfulness in marriage.
KIVATSI JONATHAN KAVUSA
doaj  

Effects of groundwater fluctuations on the distribution and population structure of two cyprinid fishes in a desert spring complex

Journal of Freshwater Ecology, 2019
Relationships between groundwater levels, surface water levels, and the distribution and habitat use of two cyprinid fishes, Least Chub (Iotichthys phlegethontis) and Utah Chub (Gila atraria), were examined at a spring complex in the Snake Valley of the ...
Mark C. Grover
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Alice Springs Town Council annual report 2015/16

, 2016
Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)

core  

HTLV-1-associated uveitis in Central Australian Indigenous adults: A case series

International Journal of Infectious Diseases, 2020
R. Chew, T. Henderson, J. Aujla, E. Whist, L. Einsiedel   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Alice Springs Town Council annual report 2006-2007

, 2007
Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT)

core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source