Results 61 to 70 of about 197,595 (287)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Importance of Strategic Social Media Marketing

Expert Journal of Marketing, 2017
Technological innovation has grown at an unprecedented rate over the past couple of decades, creating multiple opportunities for marketing in online settings.
Simona VINEREAN
doaj  

Knowledge and thresholds for palliative care and surgery among healthcare providers caring for adults with serious illness

Frontiers in Medicine
IntroductionTimely palliative care and surgical interventions improve symptoms, health-related quality of life (HRQoL), and reduce medical cost for seriously ill adults at end of life (EOL).
Darryl Wen Kai Juan, Darryl Wen Kai Juan, Irene Ai Ting Ng, Irene Ai Ting Ng, Louis Choon Kit Wong, Louis Choon Kit Wong, Wei Jing Fong, Wei Jing Fong, Piea Peng Lee, Sui An Lie, Jamie Xuelian Zhou, Mingzhe Cai, Mingzhe Cai, Johnny Chin-Ann Ong, Johnny Chin-Ann Ong, Johnny Chin-Ann Ong, Johnny Chin-Ann Ong, Johnny Chin-Ann Ong, Jane Chin Jin Seo, Jane Chin Jin Seo, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong   +25 more
doaj   +1 more source

Are aerobic fitness and repeated sprint ability linked to fatigue in professional soccer match-play? A pilot study [PDF]

, 2013
This investigation examined the association between aerobic fitness and repeated sprint ability and match-related fatigue in 9 professional outfield soccer players.
Carling, C., Dupont, G., Le Gall, F., McCall, A., Nedelec, M.,   +4 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

EFFECT OF FLYWHEEL WARM-UP ON LOWER BODY MUSCLE PERFORMANCE IN YOUTH ATHLETES [PDF]

Journal of Applied Sports Sciences
Post-activation performance enhancement (PAPE) is a phenomenon that has been used as a warm-up strategy to enhance subsequent muscular performance. The purpose of this study was to examine the efficacy of a flywheel warm-up to elicit a PAPE effect in ...
Liam Younger, Darryl Cochrane
doaj   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

“Active Mathematics”—A Classroom-Based Physical Active Learning Intervention in an Elementary School: An Experimental Pilot Study

Education Sciences
This experimental pilot study aimed to compare the amount of physical activity (PA) of children in a second-year class of an elementary school that had a mathematics class while performing PA, based on playful math games, with children that had a ...
Liliana Ramos, Vera Simões, Susana Franco   +2 more
doaj   +1 more source

Effects of Equal Volume But Different Plyometric Jump Training Intensities on Components of Physical Fitness in Physically Active Young Males [PDF]

, 2019
An 8-week single-blind randomized controlled trial was conducted to compare the effects of separate programs of equal volume, but different intensity, plyometric jump training (PJT), on physical fitness in healthy adults.
Andrade, Argus, Asadi, Balsalobre-Fernandez, Behm, Brumitt, de Villarreal, Ebben, Ebben, Ebben, Flanagan, Granacher, Hopkins, Hopkins, Lees, Markovic, Peng, Piper, Pueo, Radnor, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Randell, Read, Ronnestad, Saez-Saez de Villarreal, Sáez de Villarreal, Taube, Thomas, Trecroci, Van Lieshout, Young   +37 more
core   +2 more sources