Results 81 to 90 of about 58,392 (310)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of 2 days sodium bicarbonate loading on simulated football performance test [PDF]

, 2011
There is well-documented researches exist on sodium bicarbonate, however, not many studies have examined the effectiveness of this ergogenic aids during prolonged exercises also including a sport specific performance test.
Kurum, Orcun
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Acceleration and Maximum Running Phases in 60-m Sprint and Vertical Jump Performance

Proceedings, 2019
AIM: The purpose of the present study was to investigate the correlation between acceleration and maximum running phase in 60-m sprint and vertical jump performance.
Ilias Ntoumas, Giorgos Nounos, Pavlos Ioannidis, Vasileios Voutselas   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

EFFECT OF THE NUMBER OF SPRINT REPETITIONS ON THE VARIATION OF BLOOD LACTATE CONCENTRATION IN REPEATED SPRINT SESSIONS

, 2014
The aim of the present study was to examine the effect of number of sprint repetitions on the variation of blood lactate concentration (blood [La]) during different repeated-sprint sessions in order to find the appropriate number of sprint repetitions ...
Dardouri, W., Chamari, K., K. Chamari, Haj-Sassi, R., W. Dardouri, R. Haj-Sassi, N. Souissi, Gharbi, Z., Souissi, N., Castagna, C., Z. Gharbi, C. Castagna   +11 more
core   +1 more source

Epidemiological Profile and Antibiotic Resistance in Urinary Tract Infections Among Elderly Women

Women
Urinary tract infections (UTIs) are among the most prevalent infectious diseases in older women, especially those over 65 years of age. Physiological changes related to aging, comorbidities, and frequent use of medical devices such as urinary catheters ...
Francisco José Barbas Rodrigues, Patrícia Coelho, Sónia Mateus, João Metello, Miguel Castelo-Branco   +4 more
doaj   +1 more source

Relationship Between Linear Running and Change of Direction Performances of Male Soccer Players

Türk Spor ve Egzersiz Dergisi, 2018
It is known that there is a strong correlation between performance and match performance in terms of soccer players. Furthermore, it is expressed that the agility and the linear sprint have different performance skills.
Armağan Şahin Kafkas, Fahri Safa Çınarlı, Muhammed Emin Kafkas   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

EFFECTS OF BLOOD LACTATE ON OXYGEN UPTAKE KINETICS DURING RECOVERY AFTER SPRINT IN HUMANS [PDF]

, 2012
The purpose of this study was to examine the effects of blood lactate level (La) on oxygen uptake ( ·VO2) kinetics during recovery after short-term exercise with maximal effort (sprint). Three sprints were performed on a cycle ergometer with a load of 8%
Takuma Arimitsu, Kondou, S., Roghayyeh Afroundeh, Yunoki, Takahiro, Afroundeh, R., Chang-shun Lian, Yamanaka, Ryou, Matsuura, Ryouta, Ryouta Matsuura, Tokuo Yano, Yano, Takuro, Ryou Yamanak, Satoru Kondo, Lian, C., Takahiro Yunoki, Arimitsu, Takuma   +15 more
core   +1 more source