Results 71 to 80 of about 199,869 (309)

The Rationale for Mergers & Acquisitions in the U.S. Wireless Industry [PDF]

, 2009
The mergers between AT&T and Cingular, Sprint and Nextel, and Verizon and Alltel telecommunication companies have become the most fascinating transactions in the wireless industry.
Pereira, Eric
core   +1 more source

The effect of cooling prior to and during exercise on exercise performance and capacity in the heat: a meta-analysis [PDF]

, 2014
Exercise is impaired in hot, compared to moderate, conditions. The development of hyperthermia is strongly linked to the impairment and as a result, many different strategies have been investigated to combat this. This meta-analysis focused on one of the
Cheung, SS, Sunderland, C, Tyler, CJ
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

“Active Mathematics”—A Classroom-Based Physical Active Learning Intervention in an Elementary School: An Experimental Pilot Study

Education Sciences
This experimental pilot study aimed to compare the amount of physical activity (PA) of children in a second-year class of an elementary school that had a mathematics class while performing PA, based on playful math games, with children that had a ...
Liliana Ramos, Vera Simões, Susana Franco   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Kinematic characteristics of barefoot sprinting in habitually shod children [PDF]

, 2018
Background. Anecdotally, a wide variety of benefits of barefoot running have been advocated by numerous individuals. The influence of the alterations in the properties of the shoe on the running movement has been demonstrated in adults at submaximal ...
Keogh, Justin W.L., Koyama, Hiroyuki, Maeda, Kei, Mizushima, Jun, Ohyama-Byun, Keigo, Seki, Keitaro, Shibata, Atsushi   +6 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Building a Human Digital Twin (HDTwin) Using Large Language Models for Cognitive Diagnosis: Algorithm Development and Validation

JMIR Formative Research
BackgroundHuman digital twins have the potential to change the practice of personalizing cognitive health diagnosis because these systems can integrate multiple sources of health information and influence into a unified model ...
Gina Sprint, Maureen Schmitter-Edgecombe, Diane Cook   +2 more
doaj   +1 more source

Hot and hypoxic environments inhibit simulated soccer performance and exacerbate performance decrements when combined. [PDF]

, 2016
The effects of heat and/or hypoxia have been well-documented in match-play data. However, large match-to-match variation for key physical performance measures makes environmental inferences difficult to ascertain from soccer match-play.
Abt, Aldous, Amann, Armatas, Aughey, Balsom, Bartsch, Billaut, Billaut, Borg, Buchheit, Buono, Calbet, Castle, Cheuvront, Cheuvront, Coppel, Coull, Dellal, Dill, Drust, Duffield, Ekblom, Faude, Flouris, Garvican, González-Alonso, Goodall, Gregson, Hillman, Hommel, Lakomy, Levine, Masschelein, Mazzeo, Mohr, Mohr, Mohr, Morales-Alamo, Nassis, Nassis, Nybo, Nybo, Oliver, Périard, Racinais, Racinais, Racinais, Racinais, Ramanathan, Roelands, Sawka, Sawka, Stembridge, Stembridge, Taylor, Taylor, Taylor, Taylor, Thompson, Tonnessen, Vandenbogaerde, West, Wylie, Young, Özgünen   +65 more
core   +5 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source