Results 101 to 110 of about 42,267 (230)

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Phytochemical Composition, Health Benefits, Functional Properties, and Food Applications of Pumpkin Seeds

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Pumpkin seeds (Cucurbita spp.) are rich in bioactive compounds including proteins, unsaturated fatty acids, dietary fiber, vitamins (E and B‐complex), minerals (zinc, magnesium, iron), and phytochemicals such as phenolics, flavonoids, and phytosterols.
Messenbet Geremew Kassa, Desye Alemu Teferi   +1 more
wiley   +1 more source

Analytical Determination of Squalene in Extra Virgin Olive Oil and Olive Processing By-Products, and Its Valorization as an Ingredient in Functional Food—A Critical Review

Molecules
Squalene is a bioactive compound with significant health benefits, predominantly found in extra virgin olive oil (EVOO) and its processing by-products. This critical review explores the analytical determination of squalene in EVOO and various by-products
Laura Barp, Ana Miklavčič Višnjevec, Sabrina Moret   +2 more
doaj   +1 more source

CRISPR/Cas9 Genome Engineering in Non‐Conventional Oleaginous Yeasts: Applications, Challenges, and Prospects

Yeast, Volume 43, Issue 3, Page 77-88, May 2026.
ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias, Fernanda Pinheiro Moreira Freitas, Eduardo Luís Menezes de Almeida, Luciano Gomes Fietto, Agustin Zsögön, Wendel Batista da Silveira   +5 more
wiley   +1 more source

Endotoxin, tumor necrosis factor, and interleukin-1 decrease hepatic squalene synthase activity, protein, and mRNA levels in Syrian hamsters

Journal of Lipid Research, 1997
Recent studies have shown that endotoxin (LPS) administration to Syrian hamsters markedly increased hepatic HMG-CoA reductase activity, protein mass, and mRNA levels, but only produced a modest increase in hepatic cholesterol synthesis, suggesting that ...
R A Memon, I Shechter, A H Moser, J K Shigenaga, C Grunfeld, K R Feingold   +5 more
doaj   +1 more source

Squalene-2,3-Oxide, an Intermediate in the Enzymatic Conversion of Squalene to Lanosterol and Cholesterol

Journal of Biological Chemistry, 1967
Abstract The conversion of squalene to lanosterol by rat liver preparations in vitro has been re-examined. It has been shown that this transformation, hitherto considered to take place through the agency of one enzyme ("squalene oxidocyclase-1"), actually involves the formation of squalene-2,3-oxide as an intermediate.
J D, Willett, K B, Sharpless, K E, Lord, E E, van Tamelen, R B, Clayton   +4 more
openaire   +2 more sources

A Novel Dual‐Target Compound Designed With Potent Herbicidal and Fungicidal Activity Inspired by Conserved Phytoene Synthase Domains

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2903-2913, May 2026.
ABSTRACT The development of dual‐target inhibitors represents a cost‐effective strategy for integrated pest management. Here, we report the first dual‐target inhibitors designed against the evolutionarily conserved domain of phytoene synthase (PSY), a key enzyme in carotenoid biosynthesis.
Di Zhang, Liang Li, Chunxue Wang, Nuo Zhou, Zhilei Yu, Tianyi Shen, Baifan Wang, Qiang Bian, Dejun Ma, Yucheng Gu, Han Xu, Zhen Xi   +11 more
wiley   +1 more source

Transition from confined to bulk dynamics in symmetric star-linear polymer mixtures

, 2019
We report on the linear viscoelastic properties of mixtures comprising multiarm star (as model soft colloids) and long linear chain homopolymers in a good solvent.
Deepak, Vishnu D., Gauthier, Mario, Parisi, Daniele, Truzzolillo, Domenico, Vlassopoulos, Dimitris   +4 more
core   +3 more sources

Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry – A Review

Engineering in Life Sciences
Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and ...
Saseendran Shalu, Panam Kunnel Raveendranathan Karthikanath, Vinoth Kumar Vaidyanathan, Lars M. Blank, Andrea Germer, Palanisamy Athiyaman Balakumaran   +5 more
doaj   +1 more source