Results 121 to 130 of about 593,407 (314)

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Integrating single-cell sequencing analysis, bioinformatics analysis, and Mendelian randomization analysis to explore FABP4 prediction of prognosis and immune microenvironment in patients with lung squamous cell carcinoma

Discover Oncology
Lung cancer has a high incidence rate and lung squamous cell carcinoma accounts for about 30% of lung cancer. Due to the lack of accurate diagnosis for early stage lung squamous cell carcinoma and the limitations of treatment methods, the clinical ...
Shun Gao, Xia Long, Jiawei Li, Xialin Zhang, Youhua Wang, Sheng Lin   +5 more
doaj   +1 more source

BNC1 promotes cell migration and invasion of lung squamous cell carcinoma

陆军军医大学学报
Objective To explore the mechanism and effects of Basonuclin 1(BNC1) on the migration and invasion abilities of lung squamous cell carcinoma. Methods Bioinformatics technology was used to analyze the expression patterns and survival impact of BNC1 in ...
ZHANG Longyao, ZENG Longjin, ZHENG Linpeng   +2 more
doaj   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Ekspresi P40 Dan Ck 5/6 Pada Diagnosis Sitologi Efusi Pleura Dengan Gambaran Keganasan [PDF]

, 2017
Pleural effusion is a state of the presence of excess fluid in the pleural cavity, with 15% of cases associated with Malignancy.   This Malignancy can be caused by adenocarcinoma, squamous cell carcinoma, small cell carcinoma, mesothelioma ...
Nurprilinda, M. (Marliana)
core  

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Primary Squamous Cell Carcinoma of Thyroid: A Rare Entity

Case Reports in Pathology, 2015
Primary squamous cell carcinoma (PSCC) of thyroid is an extremely rare malignancy of thyroid. Herewith, we describe a case report of female patient who presented with neck swelling; FNAC misdiagnosed it as papillary carcinoma of thyroid but, after ...
Rahulkumar N. Chavan, Bhargav Chikkala, Cinjini Biswas, Somak Biswas, Diptendra Kumar Sarkar   +4 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Basal cell carcinoma and squamous cell carcinoma of the conjunctiva in a single lesion

American Journal of Ophthalmology Case Reports
Introduction: Basal cell carcinoma (BCC) occurrences in the conjunctiva are exceptionally rare. These lesions become exceedingly rarer next to an adjacent area of squamous cell carcinoma.
Melissa A. Trudrung, Cole Bacig, Brandon Vander Zee, Heather Potter   +3 more
doaj   +1 more source