Results 141 to 150 of about 5,567,467 (249)

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Invasive Squamous Cell Carcinoma of the Larynx in a Dog. [PDF]

Case Rep Vet Med
Frigerio ED, Bezerra SDMS, Toledo LH, Sengue BRF, Silvério MER, Senhorello ILS, de Andrade AL, Rozza DB, Machado GF.   +8 more
europepmc   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma. [PDF]

J Dent (Shiraz)
Ghaderi H, Fattahi MJ, Shirmardi Dezaki H, Malekzadeh M, Khademi B, Ghaderi A, Haghshenas MR.   +6 more
europepmc   +1 more source

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

Tracheal Squamous Cell Carcinoma in an Adult Cat. [PDF]

Vet Radiol Ultrasound
Chauhan IV, Champion CP, Froese AM, Jager MC, Tollefson CR.   +4 more
europepmc   +1 more source

Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter prospective study of 158 working‐age patients undergoing curative‐intent surgery for gastric or esophageal cancer, 78.5% were working at 18 months. Postoperative appetite loss, financial difficulties, and ≥ 10% weight loss at 6 months were associated with non‐working status.
Kentaro Goto, Shigeo Hisamori, Kohei Ueno, Hiroyasu Abe, Ryosuke Okamura, Hisahiro Hosogi, Yoshito Yamashita, Dai Manaka, Hiroaki Hata, Tatsuto Nishigori, Sanae Nakajima, Michihiro Yamamoto, Koichi Kinoshita, Shintaro Okumura, Masazumi Sakaguchi, Shigeru Tsunoda, Yu Sakagami, Koya Hida, Kazutaka Obama   +18 more
wiley   +1 more source

Sarcomatoid cutaneous squamous cell carcinoma of the heel: a rare localization of an aggressive variant of cutaneous squamous cell carcinoma. [PDF]

Oxf Med Case Reports
Farhat L, Eljouari O, Fahmi S, Gallouj S.   +3 more
europepmc   +1 more source

Squamous Cell Carcinoma Developing from an Epidermal Inclusion Cyst on the Buttock. [PDF]

Plast Reconstr Surg Glob Open
Thanapaisal C.
europepmc   +1 more source