Results 131 to 140 of about 1,427,322 (409)

Non-coding RNAs in saliva: emerging biomarkers for molecular diagnostics. [PDF]

, 2015
Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva.
Majem, Blanca, Reventós, Jaume, Rigau, Marina, Wong, David T   +3 more
core   +4 more sources

Tumor‐Informed ctDNA in Guiding First‐Line Immunochemotherapy in Advanced Non‐Small Cell Lung Cancers

Advanced Science, EarlyView.
Tumor‐informed circulating tumor DNA (ctDNA) analysis identifies patients with advanced non‐small cell lung cancer (NSCLC) who benefit from first‐line immunotherapy plus chemotherapy. Longitudinal ctDNA monitoring further reflects therapeutic response and predicts prognosis beyond imaging.
Kailun Fei, Jie Zhao, Jiachen Xu, Jianchun Duan, Chengcheng Li, Wenchuan Xie, Jia Zhong, Guoqiang Wang, Yu Xu, Boyang Sun, Rui Wan, Hua Bai, Qinxiang Guo, Wei Guo, Shangli Cai, Zhijie Wang, Jie Wang   +16 more
wiley   +1 more source

Skin Cancers Among Albinos at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 64 Cases. [PDF]

, 2012
Skin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. The challenges associated with the care of these patients are numerous and need to be addressed.
A Yakubu, AN Okoro, CJ Witkop, DD Datubo-Brown, DP Lookingbill, E Berger, Erasmus Kamugisha, ES Hong, F Kagore, G Summers, GA Alexander, Geofrey Giiti, GM Edington, Hyasinta Jaka, J Luande, Japhet M Gilyoma, JG Kromberg, Joseph B Mabula, K Glanz, KO Opara, M Terenziani, Mabula D Mchembe, ME Asuquo, ME Asuquo, Nestory Masalu, Peter Rambau, Phillipo L Chalya, PL Chalya, SA Ademiluyi, SM Hutton, Ssentongo Robert, TL Diepgen, VS Ramalingam, W Fu   +33 more
core   +3 more sources

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

miRNA-199b-5p suppresses of oral squamous cell carcinoma by targeting apical-basolateral polarity via Scribble/Lgl

Molecular Therapy: Nucleic Acids
In epithelial cells, Scribble forms cell-cell junctions and contributes to cell morphology and homeostasis by regulating apical-basolateral polarity in mammals and functions as a tumor suppressor in many carcinomas. The initial diagnosis of oral squamous
Shihyun Kim, Suyeon Park, Yong-Jae Kim, Jeongeun Hyun, Jongho Choi   +4 more
doaj   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Chemoprevention of Basal and Squamous Cell Carcinoma With a Single Course of Fluorouracil, 5%, Cream: A Randomized Clinical Trial

JAMA dermatology, 2018
Importance Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States. Objective To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma.
M. Weinstock, S. Thwin, J. Siegel, K. Marcolivio, A. Means, N. Leader, F. M. Shaw, D. Hogan, D. Eilers, S. Swetter, Suephy C. Chen, S. Jacob, E. Warshaw, G. Stricklin, R. Dellavalle, N. Sidhu-Malik, N. Konnikov, V. Werth, J. Keri, L. Robinson-Bostom, R. Ringer, R. Lew, Ryan E Ferguson, J. DiGiovanna, Grant D. Huang   +24 more
semanticscholar   +1 more source

Squamous cell carcinoma of the prostate.

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 2006
Primary squamous cell carcinoma of the prostate is an extremely uncommon malignancy, accounting for less than 0.2-1% of all prostatic cancers. We report one case of primary squamous cell carcinoma of the prostate. This patient presented with lower urinary tract symptoms with acute urinary retention after TURP.
DI PIETRO, Corradino, Celia, Antonio, DE STEFANI, Stefano, Saredi, Giovanni, BIANCHI, Giampaolo   +4 more
openaire   +2 more sources

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Prognosis and Nomogram Prediction for Patients with Oral Squamous Cell Carcinoma: A Cohort Study [PDF]

, 2023
Xinyuan Zhang, Shang Xie, Diancan Wang, Xiaofeng Shan, Zhigang Cai   +4 more
openalex   +1 more source