Results 51 to 60 of about 1,427,322 (409)

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Nature Communications, 2020
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the composition of ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 ...
Xiannian Zhang, Linna Peng, Yingying Luo, Shaosen Zhang, Yang Pu, Yamei Chen, Wenjia Guo, Jiacheng Yao, Mingming Shao, W. Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xia Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce-jun Zhong, W. Tan, Jianbin Wang, Chen Wu, D. Lin   +24 more
semanticscholar   +1 more source

Endoglin and squamous cell carcinomas

Frontiers in Medicine, 2023
Despite the fact that the role of endoglin on endothelial cells has been extensively described, its expression and biological role on (epithelial) cancer cells is still debatable. Especially its function on squamous cell carcinoma (SCC) cells is largely unknown.
Sarah K. Hakuno, Stefanus G. T. Janson, Marjolijn D. Trietsch, Marjolijn D. Trietsch, Manon de Graaf, Manon de Graaf, Eveline de Jonge-Muller, Stijn Crobach, Tom J. Harryvan, Jurjen J. Boonstra, Winand N. M. Dinjens, Marije Slingerland, Lukas J. A. C. Hawinkels   +12 more
openaire   +5 more sources

Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study [PDF]

, 2019
Background: More than 90% of malignant tumors diagnosed in the oral cavity are Oral Squamous Cell Carcinomas (OSCC) whose preferred location is the tongue.
Cebrián Carretero, José Luis, López Sánchez, Antonio Francisco, Martínez García, Miguel Angel, Migueláñez Medrán, Carmen, Pozo Kreilinger, José Juan   +4 more
core   +3 more sources

Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma

Tumor Biology, 2017
Differentiation is a major histological parameter determining tumor aggressiveness and prognosis of the patient; cancer stem cells with their slow dividing and undifferentiated nature might be one of the factors determining the same.
Simple Mohanta, Gangotri Siddappa, Sindhu Govindan Valiyaveedan, Ravindra Dodda Thimmasandra Ramanjanappa, Debashish Das, Ramanan Pandian, Samanta Sekhar Khora, Moni Abraham Kuriakose, Amritha Suresh   +8 more
doaj   +1 more source

Immunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma

Indian Journal of Ophthalmology, 2022
Purpose: Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on ...
Perumal Jayaraj, Seema Sen, Kartikey Saxena, Jassika Gupta, Pranjal Vats, Seema Kashyap, Sheetal Chauhan, Neelam Pushker   +7 more
doaj   +1 more source

Cutaneous Squamous Cell Carcinoma: From Biology to Therapy

International Journal of Molecular Sciences, 2020
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic.
R. Corchado-Cobos, N. García-Sancha, R. González-Sarmiento, J. Pérez-Losada, J. Cañueto   +4 more
semanticscholar   +1 more source

The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma [PDF]

, 2011
Aims: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood. Human papillomavirus (HPV) may be involved in carcinogenesis, but few studies have compared cell-cycle protein expression in HPV positive and negative cancers.
Backes, Bezerra, Bleeker, Cubilla, Daling, De Vuyst, Eichten, Ferreux, Fife, Funk, Funk, Gargiulo, Gartel, Gregoire, Guerrero, Hafkamp, Koyamatsu, Lam, Lam, Lont, Lopes, Lu, Martins, Munoz, Nam, Narayana, Nevins, Pascual, Prowse, Robinson, Rubin, Sano, Senba, Shoji, Sobin, Stankiewicz, Trimble, Vousden, Yanagawa   +38 more
core   +4 more sources

Assessment of Intratumoral and Peritumoral Computed Tomography Radiomics for Predicting Pathological Complete Response to Neoadjuvant Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma

JAMA Network Open, 2020
Key Points Question Are peritumoral radiomics features extracted from pretreatment computed tomography images predictive of pathological complete response following neoadjuvant chemoradiation in patients with esophageal squamous cell carcinoma?
Yihuai Hu, C. Xie, Hong Yang, J. Ho, J. Wen, Lu-Jun Han, Keith W H Chiu, J. Fu, V. Vardhanabhuti   +8 more
semanticscholar   +1 more source

Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: A review of the National Cancer Database [PDF]

, 2017
For elderly patients with locally advanced esophageal cancer, therapeutic approaches and outcomes in a modern cohort are not well characterized. Patients ≥70 years old with clinical stage II and III esophageal cancer diagnosed between 1998 and 2012 were ...
Bradley, Jeffrey D, Kozower, Benjamin, Lockhart, A. Craig, Meyers, Bryan F, Parikh, Parag J, Perkins, Stephanie M, Puri, Varun, Roach, Michael C, Robinson, Cliff G, Samson, Pamela P, Vlacich, Gregory   +10 more
core   +2 more sources

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]

, 2018
The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk, Kang, Hyunseok, Mehra, Ranee   +2 more
core   +2 more sources