Results 61 to 70 of about 593,407 (314)

Lung carcinoma: its profile and changing trends [PDF]

, 2010
BACKGROUND: Lung Carcinoma is the leading causes of morbidity and mortality worldwide with an incidence of 1.3 million cases per year. This study was undertaken to determine prevalence of various histological types of lung carcinoma and to analyse their ...
Ali, Mahrukh Ayesha, Ali, Mohammed Usman, Nasreen, Shagufta, Shah, Noreen, Siddiqui, Saad   +4 more
core   +1 more source

Basaloid squamous cell carcinoma

Journal of Oral and Maxillofacial Pathology, 2021
Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma characterized by a conglomerate of clinically aggressive course and disparate histopathological features. It is frequently seen in upper aerodigestive tract area.
Santhosh Manikandan, V. Jai, Krishna, P. Sai, Makesh Raj, L. S., Sekhar, Prasanna   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Maintenance of head and neck tumor on-chip: gateway to personalized treatment? [PDF]

, 2017
Aim: Head and neck squamous cell carcinomas (HNSCC) are solid tumors with low overall survival (40–60%). In a move toward personalized medicine, maintenance of tumor biopsies in microfluidic tissue culture devices is being developed. Methodology/ results:
Bower, Ruth, Crank, Stephen T, Green, Victoria L., Greenman, John, Karsai, Laszlo, Kuvshinov, Dmitriy, Kuvshinova, Elena, Stafford, Nicholas D   +7 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
A Jemal, A Muller, A Pellegrino, A Zhu, A Zipin-Roitman, AF Ziober, AM Mulligan, BJ Moeller, BK Lo, C Beskow, C Grandi, CC Tong, CJ Hutchings, CL Addison, CT Allen, D Sano, E Montagna, Göran Laurell, HA Wolff, IK Kalnins, J Romanini, J Vandercappellen, J Wang, JN Sarkaria, K Annertz, K Kawada, K Kawada, KA Dinshaw, Karin Nylander, KB Pytynia, L Boldrup, L Goldberg-Bittman, L Lundqvist, Lotta Loljung, M Cojoc, M Fujita, M Liu, M Rentoft, M Rentoft, Matilda Rentoft, MF Calmon, MN Wente, N Sahu, P Silva, Philip John Coates, S Atula, S Friesland, S Matsumura, S Shintani, S Struyf, SP Schantz, SP Schantz, TC Walser, Torben Wilms, W Garavello, WA Yeudall, XL Lu, Y Matsuo   +57 more
core   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone

Tumor Biology, 2017
Most primarily cultured laryngeal squamous cell carcinoma cells are difficult to propagate in vitro and have a low survival rate. However, in our previous work to establish a laryngeal squamous cell carcinoma cell line, we found that laryngeal cancer ...
Mei Wang, Chunping Wu, Yu Guo, Xiaojuan Cao, Wenwei Zheng, Guo-Kang Fan   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma [PDF]

, 2011
Aims: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood. Human papillomavirus (HPV) may be involved in carcinogenesis, but few studies have compared cell-cycle protein expression in HPV positive and negative cancers.
Backes, Bezerra, Bleeker, Cubilla, Daling, De Vuyst, Eichten, Ferreux, Fife, Funk, Funk, Gargiulo, Gartel, Gregoire, Guerrero, Hafkamp, Koyamatsu, Lam, Lam, Lont, Lopes, Lu, Martins, Munoz, Nam, Narayana, Nevins, Pascual, Prowse, Robinson, Rubin, Sano, Senba, Shoji, Sobin, Stankiewicz, Trimble, Vousden, Yanagawa   +38 more
core   +4 more sources