Results 91 to 100 of about 2,525,619 (266)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Insights into the spatial distribution of global, national, and subnational greenhouse gas emissions in the Emissions Database for Global Atmospheric Research (EDGAR v8.0) [PDF]
Earth System Science DataTo mitigate the impact of greenhouse gas (GHG) and air pollutant emissions, it is of utmost importance to understand where emissions occur. In the real world, atmospheric pollutants are produced by various human activities from point sources (e.g.
M. Crippa +14 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Antarctic Ozone Enhancement During the 2019 Sudden Stratospheric Warming Event
Geophysical Research Letters, 2020 We analyze the 2019 sudden stratospheric warming event that occurred in the Southern Hemisphere through its impact on the Antarctic ozone. Using temperature, ozone, and nitric acid data from the Infrared Atmospheric Sounding Interferometer (IASI), our ...
Sarah Safieddine +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Monomial ideals with tiny squares
, 2018 Let $I \subset K[x,y]$ be a monomial ideal. How small can $\mu(I^2)$ be in terms of $\mu(I)$? It has been expected that the inequality $\mu(I^2) > \mu(I)$ should hold whenever $\mu(I) \ge 2$.
Eliahou, Shalom +2 more
core
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
International Journal of Mathematics and Mathematical Sciences, 2016 The definition of a regular magic square motivates us to introduce the new special magic squares, which are reflective magic squares, corner magic squares, and skew-regular magic squares.
Thitarie Rungratgasame +4 more
doaj +1 more source