Results 41 to 50 of about 977 (245)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Effect of Relative Movement between the Shroud and Blade on Tip Leakage Flow Characteristics
Energies, 2017 An experimental and numerical investigation into the tip leakage flow of a turbine rotor is carried out using a particle image velocimetry (PIV) system and the commercial software ANSYS CFX 14.0.
Xiaochun Wang +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
International Journal of Turbomachinery, Propulsion and Power, 2019 Rotor tip film cooling is investigated at the Large Scale Turbine Rig, which is a 1.5-stage axial turbine rig operating at low speeds. Using pressure sensitive paint, the film cooling effectiveness η at a squealer-type blade tip with ...
Manuel Wilhelm, Heinz-Peter Schiffer
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Uncertainty quantification of leakages in a multistage simulation and comparison with experiments [PDF]
, 2016 The present paper presents a numerical study of the impact of tip gap uncertainties in a multistage turbine. It is well known that the rotor gap can change the gas turbine efficiency but the impact of the random variation of the clearance height has not ...
Ahlfeld, R +3 more
core
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Advances in the Aerothermal Performance Enhancement of Turbine Blade Tip Configurations
EnergiesA clearance necessarily exists between the blade tip and the casing in turbines. A leakage flow, formed by the accelerated gas through the tip clearance, is a major cause of turbine stage efficiency loss.
Bin Wu +4 more
doaj +1 more source