Results 51 to 60 of about 402 (231)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Advances in the Aerothermal Performance Enhancement of Turbine Blade Tip Configurations

Energies
A clearance necessarily exists between the blade tip and the casing in turbines. A leakage flow, formed by the accelerated gas through the tip clearance, is a major cause of turbine stage efficiency loss.
Bin Wu, Lei Ren, Renyi Wen, Chenrui Yang, Daren Zheng   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

NUMERICAL ANALYSIS OF FLOW IN ULTRA-HIGHLY LOADED TURBINE CASCADE WITH SQUEALER TIP : EFFECTS OF SQUEALER TIP CONFIGURATION

, 2019
The objective of this study is to investigate the effectiveness of the squealer tip on UHLTC with the turning angle 160 degrees arranged in annular by using a numerical method. The numerical calculations for the internal flows of UHLTC were performed for
田澤 紘之
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Effects of cutback squealer tips on the vortices and local loss in the tip region of axial turbine rotor

Propulsion and Energy
Tip leakage loss is a significant source of aerodynamic loss in the turbine rotor and can be controlled by using a cavity tip. In this paper, three configurations with cutback rims are numerically investigated to control the formation and development of ...
Weihao Zhang, Yufan Wang, Kailai Chen, Dongming Huang   +3 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

A Coandă-Surface-Assisted Ejector as a Turbine Tip Leakage Mitigator

International Journal of Turbomachinery, Propulsion and Power
This paper presents an experimental and computational investigation of novel, ejector-based, Coandă-surface-assisted tip leakage mitigation schemes.
Gohar T. Khokhar, Cengiz Camci
doaj   +1 more source

New correlations for the average Nusselt number in squealer turbine blade tip [PDF]

, 2014
Paper presented to the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 14-16 July 2014.Numerical simulations of the flow field and heat transfer of squealer blade tip are performed in this study.
Ghenai, C., Janajreh, I., Madani, M.
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