Results 41 to 50 of about 402 (231)

Effect of blade squealer tips on aerodynamic performance and stall margin in a transonic centrifugal compressor with vaned diffuser

open access: yes, 2022
In order to enhance the aerodynamic performance of a centrifugal compressor with a vaned diffuser while also improving its stall margin, squealer tip cavities were applied to the tips of the impeller blades.
Minsuk Choi   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Effect of Relative Movement between the Shroud and Blade on Tip Leakage Flow Characteristics

open access: yesEnergies, 2017
An experimental and numerical investigation into the tip leakage flow of a turbine rotor is carried out using a particle image velocimetry (PIV) system and the commercial software ANSYS CFX 14.0.
Xiaochun Wang   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Experimental Investigation of Rotor Tip Film Cooling at an Axial Turbine with Swirling Inflow Using Pressure Sensitive Paint

open access: yesInternational Journal of Turbomachinery, Propulsion and Power, 2019
Rotor tip film cooling is investigated at the Large Scale Turbine Rig, which is a 1.5-stage axial turbine rig operating at low speeds. Using pressure sensitive paint, the film cooling effectiveness η at a squealer-type blade tip with ...
Manuel Wilhelm, Heinz-Peter Schiffer
doaj   +1 more source

Average Nusselt Number for Pressure and Suction Sides of Squealer Turbine Blade Tip

open access: yes, 2011
Numerical simulations of the flow field and heat transfer of squealer blade tip are performed in this study. The effect of Reynolds number (Re = 10000–40000), the clearance gap to width ratios (C/W = 5%–15%) and the cavity depth to width ratios (D/W = 10%
Chaouki Ghenai
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Influence of Tip Injection and Film Cooling for Blade Tip Flow and Heat Transfer

open access: yes, 2011
A numerical based study was conducted to further understanding of turbine tip leakage and flow mechanisms for squealer tip blade. Three blade geometry models with different tips are established.
Zhu Feng Yue   +3 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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