Results 41 to 50 of about 29,360 (257)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

open access: yesAdvanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang   +16 more
wiley   +1 more source

Combining Adversarial Guarantees and Stochastic Fast Rates in Online Learning [PDF]

open access: yes, 2016
We consider online learning algorithms that guarantee worst-case regret rates in adversarial environments (so they can be deployed safely and will perform robustly), yet adapt optimally to favorable stochastic environments (so they will perform well in a
Grünwald, Peter   +2 more
core   +1 more source

Terahertz Channel Modeling, Estimation and Localization in RIS‐Assisted Systems

open access: yesAdvanced Electronic Materials, EarlyView.
Reconfigurable intelligent surfaces have become a recent intensive research focus. Based on practical applications, channel strategies for RIS‐assisted terahertz wireless communication systems are categorized into three different types: channel modeling, channel estimation, and channel localization.
Hongjing Wang   +9 more
wiley   +1 more source

Comparison of psychosocial and emotional consequences of childhood strabismus on the families from rural and urban India

open access: yesIndian Journal of Ophthalmology, 2009
Purpose : To compare the psychosocial consequences of horizontal comitant strabismus in children between the families of urban and rural India. Materials and Methods : In this cohort study, an eight-question quality-of-life instrument was administered ...
Kothari Mihir   +3 more
doaj  

Lipschitz Adaptivity with Multiple Learning Rates in Online Learning [PDF]

open access: yes, 2019
We aim to design adaptive online learning algorithms that take advantage of any special structure that might be present in the learning task at hand, with as little manual tuning by the user as possible. A fundamental obstacle that comes up in the design
Koolen, Wouter M.   +2 more
core   +1 more source

Magnetic Fields in Dark Cloud Cores: Arecibo OH Zeeman Observations

open access: yes, 2008
We have carried out an extensive survey of magnetic field strengths toward dark cloud cores in order to test models of star formation: ambipolar-diffusion driven or turbulence driven.
Nakano T.   +5 more
core   +1 more source

Detection of Circular Polarization in the Galactic Center Black Hole Candidate Sagittarius A* [PDF]

open access: yes, 1999
We report here the detection of circular polarization in the Galactic Center black hole candidate, Sagittarius A*. The detection was made at 4.8 GHz and 8.4 GHz with the Very Large Array.
Donald C. Backer   +5 more
core   +3 more sources

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken   +4 more
wiley   +1 more source

Case Report With Biallelic Variants in GCNT2 Implicates Exon 1B in Congenital Cataracts

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT GCNT2‐related cataracts is a disorder characterized by bilateral congenital cataracts (CC) of various types (with or without the adult i blood phenotype) and is caused by biallelic variants in GCNT2, which has 3 major isoforms, differentiated by alternative splicing of the first exon (known as exon 1A, B, and C).
Audrey O'Neill   +5 more
wiley   +1 more source

Two Dimensional Position Correction Algorithm for High-Squint Synthetic Aperture Radar in Wavenumber Domain Algorithm

open access: yesRemote Sensing
In the traditional high squint angle ω−k imaging algorithm, the impact of a high squint angle on azimuth and range positioning is not considered but does include two aspects: the azimuth position shift caused by a high squint angle and the impact of ...
Shuai Wang   +5 more
doaj   +1 more source

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