Results 81 to 90 of about 878,007 (304)
Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI [PDF]
Journal of Lipid Research, 2007 Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E (apoE) [double knockout (DKO) mice] develop dyslipidemia, accelerated atherosclerosis, and myocardial infarction, and die prematurely. We examined effects of apoE and SR-BI deficiency on macrophage cholesterol homeostasis.
Evelyn E. Griffin +7 more
openaire +4 more sources
Current Advances of Antibacterial Biomaterials for Bone Regeneration
Advanced Materials Interfaces, EarlyView.Effective treatment of infectious bone defects requires not only robust bone regeneration, but also the elimination of bacterial infection. This review highlights current cutting‐edge concepts and innovations in synthetic bone repair biomaterials and antibacterial bone repair materials, aiming to promote clinical translation and inspire broader ...
Xueping Kong +3 more
wiley +1 more source
Chemical Bonds Containing Hydrogen: Choices for Hydrogen Carriers and Catalysts
Angewandte Chemie, EarlyView.Hydrogen carriers utilizing B─H, C─H, N─H, and O─H bonds are evaluated for their potential in hydrogen storage and release. Key candidates such as methanol, ammonia, and formic acid are examined with a focus on critical factors influencing performance, including the nature of chemical bonds, reaction pathways, and catalytic processes.
James Cashel +9 more
wiley +2 more sources
Scaled‐Up Graphene Growth Through Chemical Vapor Deposition Over Large‐Area Liquid Cu Catalysts
Advanced Materials Interfaces, EarlyView.Scaling up the catalyst area fivefold and improving molten catalyst cleaning minimize reactor kinetic effects, enabling reaction kinetics to dominate graphene growth. This results in high‐quality graphene with controlled layering and measurable nucleation rates.
Mahesh K. Prabhu +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee +19 more
wiley +2 more sources
Advanced Materials Interfaces, EarlyView.Polyvinyl pyrrolidone passivation enhances TiO2/CsPbI2Br interfaces, suppressing recombination and improving photodetector performance with faster response, higher photoresponsivity, and superior detectivity. Abstract Inorganic perovskites hold immense promise for optoelectronic applications, but their performance is often hindered by defects and trap ...
Shruti Shah +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.The ammonothermal method enabled the synthesis of antiperovskites with NH2−‐groups instead of N3−‐ ions, which introduces vacancies and replaces the octahedral unit by square‐pyramidal units. These imide‐based defect‐antiperovskites AE5AsPn(NH)2 (AE=Ca, Sr; Pn=Sb, Bi) showcase a new route to structurally engineer antiperovskites with cation ...
Thanh G. Chau +8 more
wiley +2 more sources
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions
Journal of Lipid Research, 2021 : HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May +3 more
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STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy
Advanced Science, EarlyView.STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken +3 more
wiley +1 more source
Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI
Journal of Lipid Research, 2007 Treatment of atherosclerotic disease often focuses on reducing plasma LDL-cholesterol or increasing plasma HDL-cholesterol. We examined in vitro the effects on HDL receptor [scavenger receptor class B type I (SR-BI)] activity of three classes of clinical
Thomas J.F. Nieland +6 more
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