Results 101 to 110 of about 1,036,062 (294)

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Regulation of adrenal scavenger receptor-BI expression by ACTH and cellular cholesterol pools

Journal of Lipid Research, 1999
Scavenger receptor BI (SR-BI) mediates selective uptake of high density lipoprotein (HDL) cholesteryl ester in the liver and adrenal gland. Adrenal SR-BI is increased both in adrenocorticotropic hormone (ACTH)-treated mice and also in apolipoprotein A-I ...
Yu Sun, Nan Wang, Alan R. Tall
doaj   +1 more source

Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI [PDF]

Journal of Lipid Research, 2007
Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E (apoE) [double knockout (DKO) mice] develop dyslipidemia, accelerated atherosclerosis, and myocardial infarction, and die prematurely. We examined effects of apoE and SR-BI deficiency on macrophage cholesterol homeostasis.
Patricia G. Yancey, Jerome W. Gray, Yu Hong, Evelyn E. Griffin, Brian E. Cox, Vladimir R. Babaev, Fazio Sergio, MacRae F. Linton   +7 more
openaire   +3 more sources

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice

Journal of Lipid Research, 2004
Scavenger receptor class B type I (SR-BI) has been identified as a functional HDL binding protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL.
Ruud Out, Menno Hoekstra, John A.A. Spijkers, Johan K. Kruijt, Miranda van Eck, Ingrid S.T. Bos, Jaap Twisk, Theo J.C. Van Berkel   +7 more
doaj   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI

Journal of Lipid Research, 2007
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocytosis ...
Bing Sun, Boris B. Boyanovsky, Margery A. Connelly, Preetha Shridas, Deneys R. van der Westhuyzen, Nancy R. Webb   +5 more
doaj   +1 more source

Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production

Biochimica et Biophysica Acta, 2014
The mammalian target of rapamycin (mTOR) inhibiting drug rapamycin (Sirolimus) has severe side effects in patients including hyperlipidemia, an established risk factor for atherosclerosis.
Stefanie Fruhwürth, S. Krieger, Katharina Winter, M. Rosner, M. Mikula, T. Weichhart, R. Bittman, M. Hengstschläger, H. Stangl   +8 more
semanticscholar   +1 more source

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles.
Trigatti, BL, Krieger, M, Rigotti, A
openaire   +4 more sources

Multi‐Channel Electrically Tunable Varifocal Metalens With Compact Multilayer Polarization‐Dependent Metasurfaces and Liquid Crystals

Advanced Science, EarlyView.
A compact eight‐channel electrically tunable varifocal metalens with three single‐layer polarization‐multiplexed bi‐focal metalens and three LC cells. The total thickness of the device is ∼6 mm, while the focal lengths can be switched among eight values (3.6, 4.2, 4.5, 4.9, 6.2, 6.9, 8.4, and 9.6 mm). ABSTRACT As an essential module of optical systems,
Zhiyao Ma, Yize Liu, Zhe Li, Tian Tian, Yuxuan Liao, Xue Feng, Yongzhuo Li, Kaiyu Cui, Fang Liu, Hao Sun, Wei Zhang, Yidong Huang   +11 more
wiley   +1 more source