Results 31 to 40 of about 901,731 (281)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative Study on Monolithic Zirconia and Lithium Disilicate

Journal of Pharmacy and Bioallied Sciences
Background: In recent years, patient awareness and demands for dental aesthetic have increased tremendously. Aim: To compare between MZ and DL for SR and CR. Material and Method: A total of 64 samples were included and divided into two groups, i.e. A and
Anup Patil, Manish R. Bhise, Shivsharan Dhadde, Lishoy W. Rodrigues, Pratiksha Jadhav, Pushkar Gupta   +5 more
doaj   +1 more source

Changes in serum cholyglycine and prealbumin levels, glutamyl transpeptidase, and Alpha-fetoprotein after transcatheter arterial chemoembolisation combined with microwave ablation of liver cancer [PDF]

Journal of Medical Biochemistry
Background: This study aimed to evaluate the clinical outcomes of transcatheter arterial chemoembolisation (TACE) alone and in combination with microwave ablation (MWA) for patients with middle- or advanced-stage primary liver cancer (PLC) and analyse ...
Chen Kang, Zhang Chaojie, Sun Feihu, Sun Lei, Fan Chen, Wang Weidong   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pemberian EM4 (Effective Microorganisme 4) Hasil Kultur dalam Media yang Berbeda pada Pakan untuk Budi daya Lele (Clarias sp.)

Jurnal Riset Biologi dan Aplikasinya, 2019
Ikan lele (Clarias sp.) merupakan salah satu komoditas perikanan air tawar yang banyak diminati di Indonesia dan terjadi peningkatan produksinya setiap tahun. Untuk itu, terus dipacu peningkatan produksi ikan lele. Upaya yang dilakukan untuk meningkatkan
Mohhamad Yunus Anis, Dyah Hariani
doaj   +1 more source

Development of a new measure to check attitude towards water conservation✰

MethodsX, 2023
Water Conservation is the need of the hour and attitudes towards conserving the resources is what is sure to become a priority in the coming years. In order to understand what could influence the change in attitude and thereby bring about a change of ...
R. Archana Reddy, Rakesh Sengupta, B. Micheal Jackson, Christelle Lewis   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Prospects for the discovery of strategic mineral deposits (Cu, Co, Ni, EPG, Sc, V, Li, REE, Sr, graphite, hydrocarbons) in the diamond-bearing areas of the South of Western Yakutia

Известия высших учебных заведений: Геология и разведка
Background. There are prerequisites, signs and manifestations of deposits of strategic types of mineral raw materials Cu, Co, Ni, EPG, Sc, V, REE, hydrocarbons and graphite within the Nakyn, Mirninsky and Syuldyukarsky diamond-bearing fields, which are ...
P. A. Ignatov, R. U. Eremenko, A. V. Tolstov, I. M. Ovchinnikov   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source