Results 41 to 50 of about 464,671 (242)

The use of energy dispersive X-ray spectroscopy to detect strontium marks in fish otoliths

Scientia Marina, 2012
Otolith marking provides a reference point for otolith growth patterns by validating the temporal significance of growth increments. This widespread method is primarily implemented using fluorescent dyes.
Beatriz Morales-Nin, José Manuel Fortuño, Sílvia Pérez-Mayol, Amalia Grau   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Surgical systematic reviews: best available evidence or disposable waste?

Innovative Surgical Sciences
Evidence-based medicine demands treatment options for patients to be based on the current best available evidence. Systematic reviews (SRs) with meta-analyses allow surgeons to make therapeutical decisions in accordance with the highest level of evidence.
Klotz Rosa, Tenckhoff Solveig, Probst Pascal   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Occurrence characteristics of Sr in coal from Tashan Coal Mine in Datong,Shanxi Province

Meitan kexue jishu
Datong Coalfield was intruded by igneous intrusions in both the Indosinian (Late Permian to the end of the Triassic) and the Yanshan (Late Jurassic to the Early Cretaceous) periods，which caused contact metamorphism of the coal seam. Previous studies have
Changyu MEN, Xiaoxia SONG, Hongtao MA, Wei LI, Jiwei YAN, Wenxuan GAO   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

MAGMATIC SOURCES OF THE EVOLVING CONTINENTAL TECTONOSPHERE IN INDIA: GENERATION OF ALKALINE IGNEOUS COMPLEXES WITH CARBONATITES IN THE SAMALPATTI (SOUTHERN INDIA) AND AMBA DONGAR (WESTERN INDIA) MASSIFS

Геодинамика и тектонофизика
Neoproterozoic Samalpatti and Cretaceous-Paleogene Amba Dongar massifs are considered to evaluate the change of sources of carbonatite magmatism in evolving tectonosphere of India. The inherited character of Ba and Sr distribution components is traced in
S. V. Rasskazov, T. A. Yasnygina, K. R. Hari, I. S. Chuvashova, E. V. Saranina   +4 more
doaj   +1 more source

Alcohol septal ablation for hypertrophic obstructive cardiomyopathy – 8 years follow up

Indian Heart Journal, 2014
Background: Alcohol septal ablation is emerging as an alternative to surgical myectomy in the management of symptomatic cases of Hypertrophic obstructive cardiomyopathy (HOCM).
I. Sathyamurthy, Rajeshwari Nayak, Abraham Oomman, K. Subramanyan, Mathew Samuel Kalarical, Robert Mao, P. Ramachandran   +6 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source