LL‐37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease
Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.ABSTRACT Human cathelicidin peptide LL‐37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions of LL‐37 in the intestinal‐immune axis and its contribution to intestinal immune homeostasis. A
Qichao Liu, Peng Xu, Cheng Zhang
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Inhibition of Src Family Kinases Ameliorates LPS-Induced Acute Kidney Injury and Mitochondrial Dysfunction in Mice. [PDF]
Int J Mol Sci, 2020 Pak ES, Uddin MJ, Ha H.
europepmc +1 more source
Impact of organic pollutants on phenotype and gene expression in human breast cancer cells
Journal of Applied Toxicology, Volume 46, Issue 5, Page 1487-1505, May 2026.ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin +7 more
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Src family kinases-mediated negative regulation of sperm acrosome reaction in chickens (Gallus gallus domesticus). [PDF]
PLoS One, 2020 Priyadarshana C +3 more
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Octreotide Counteracts IFN‐γ‐Induced Endothelial Inflammation
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.ABSTRACT Endothelial cells maintain vascular homeostasis through the regulation of permeability and coagulation. Interferon‐gamma (IFN‐γ), a proinflammatory cytokine released by activated T lymphocytes and natural killer cells, disrupts endothelial junctional integrity, leading to barrier dysfunction.
Saikat Fakir +3 more
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Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies
MedComm, Volume 7, Issue 5, May 2026.The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He +9 more
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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. [PDF]
Cancers (Basel), 2020 Jin W.
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Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
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Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
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Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far. [PDF]
Cancers (Basel), 2020 Martellucci S +5 more
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